What Types of Breast Cancer Have the Highest Recurrence Rates?

What other risk factors influence recurrence?

The type of breast cancer you have is a large risk factor for recurrence, but it’s not the only one. There are many other factors that can increase your chances of recurrence. These include:

• Stage at diagnosis: The stage of your cancer at diagnosis influences your risk of recurrence. A high stage increases your risk.
• Lymph node involvement: Cancers that spread to your lymph nodes are more likely to recur.
• Tumor size: Large tumors increase your risk of recurrence.
• Tumor margins: A tumor margin is a border between a tumor and the healthy tissue that surrounds it. After a tumor is removed, a sample of the border area is removed and studied in a lab. If any cancer cells are found in this area, it’s called a “positive tumor margin.” This increases your risk of recurrence.
• ER status: ER-positive breast cancer cells can use estrogen to grow and reproduce. These cancers have a higher risk of recurrence and can sometimes recur decades later.
• HER2 status: HER2 is a protein often found in people who have breast cancer. High amounts of this protein can increase your risk of recurrence.
• BRCA status: Having BRCA1 and BRCA2 gene mutations puts you at a greater risk of recurrence and developing other types of cancers.
• Radiation therapy: Electing not to have radiation therapy after a lumpectomy can increase your risk of recurrence. Not completing or receiving other recommended treatments, such as chemotherapy, immunotherapy, endocrine therapy, or targeted therapy, can also increase your risk of recurrence.
• Endocrine therapy: If you have hormone-positive breast cancer, your doctor will typically recommend receiving endocrine therapy treatment. Not completing or receiving other recommended treatments, such as chemotherapy, immunotherapy, radiation therapy, or targeted therapy, can also increase your risk of recurrence.
• Age: Developing breast cancer while younger than 35 years of age increases your risk of developing breast cancer again.
• Obesity: A higher body mass index (BMI) increases your risk of recurrence.
• Sedentary lifestyle: A sedentary lifestyle can increase your risk of recurrence.
• Smoking: SmokingTrusted Source can also increase your risk of recurrence.

  What types of breast cancer are most likely to recur?

  Aggressive breast cancers are harder to treat, more likely to spread, and more likely to recur. The two types of breast cancer most likely to recur are inflammatory breast cancer (IBC) and triple-negative breast cancer (TNBC). These cancers are described in more detail below.

  • IBC: IBC is a rare and invasive type of breast cancer. About 1–5%Trusted Source of all people’s breast cancer is IBC. IBC causes cancer cells to block lymph vessels in your breast tissue. Lymph vessels are the small tubes that drain lymph fluid from your breast. IBC spreads quickly and is usually stage 3 at the time of diagnosis.
  • TNBC: About 10–15%Trusted Source of all people’s breast cancer is TNBC. Cancer cells that cause TNBC don’t have estrogen receptors (ERs) or progesterone receptors (PRs) and don’t make any, or much, of a breast cancer-associated protein called HER2. TNBC spreads faster than most other types of breast cancer and has few treatment options.The risk of breast cancer recurrence is highest within the first two years after the initial diagnosis but decreases over time, emphasizing the importance of regular mammograms for those in remission.

    Although the type of breast cancer you have plays a large role in its recurrence, it’s not the only factor.

    Breast cancer variables such as tumor size and stage at diagnosis can also influence your risk. Personal factors such as your age and your weight can affect your risk as well.

    In this article, we take a closer look at the types of breast cancer most likely to recur and other factors that can increase your risk of recurrence.

    What is recurrence in breast and other cancers?

    Cancer can sometimes come back after initial treatment is completed. The cancer might come back in:

    • the place it started (local recurrence)
    • the lymph nodes near the site of your original cancer (regional recurrence)
    • another part of your body (distant recurrence)

    Fast-growing cancers and cancers that were diagnosed at an advanced stage, are more likely to return.

How often should a person with breast cancer in remission receive screening for recurrence?

If you had a lumpectomy or a partial mastectomy, you’ll typically have a mammogram 6 months to a year after surgery and radiation. During this first year, you’ll likely also have monitoring appointments with your doctor or oncologist.

After your initial postcancer mammogram, yearly mammograms are recommended. If you’ve had a complete mastectomy, you won’t need a mammogram on that side, but you’ll still need to have yearly mammograms on your remaining breast.

Depending on your individual breast cancer risk factors and your breast density, a doctor may also recommend yearly ultrasounds, MRIs, or both.