Source: University of Texas M. D. Anderson Cancer Center From: news-medical.net Researchers at The University of Texas MD Anderson Cancer Center have developed a new computational approach designed to better account for changes in gene expression within tumors relative to their unique microenvironments. This approach outperformed current methods for predicting chemotherapy response in patients with triple-negative breast cancer (TNBC). The …
Triple negative breast cancer cells use new strategy to boost metastatic ability
Source: Baylor College of Medicine From: news-medical.net Researchers at Baylor College of Medicine have uncovered a strategy that triple negative breast cancer (TNBC) cells use to boost their ability to metastasize, or spread to other organs. Metastasis is the leading cause of cancer-related deaths and scientists are investigating ways to prevent it. These findings, published in Nature Communications, highlight new …
Purdue researchers discover new therapeutic target for triple-negative breast cancer
Source: Purdue University From: news-medical.net A Purdue University team led by Kyle Cottrell has discovered a new therapeutic target for triple-negative breast cancer. Cottrell, biochemistry graduate student Addison Young and their co-authors describe the discovery in the journal RNA. The laboratory research spotlights double-stranded ribonucleic acid (dsRNA)-binding proteins. “Generally, people are taught in high school biology that RNA is single-stranded. …
Study identifies PUF60 as a critical vulnerability in triple negative breast cancer
Source: University of California – San Diego From: news-medical.net Researchers at University of California San Diego have identified a previously unrecognized treatment target for triple‑negative breast cancer (TNBC), the most aggressive subtype of breast cancer. Their new study reveals that a protein called PUF60 plays an essential role in helping TNBC cells grow and survive by controlling how key genes …
New Antibody Halts One of the Deadliest Breast Cancers
By: Medical University of South Carolina From: scitechdaily.com Scientists have uncovered a powerful new antibody that disrupts a key protein helping triple-negative breast cancer survive and evade immunity. Triple-negative breast cancer (TNBC) is considered one of the most aggressive and difficult forms of breast cancer to treat. It grows rapidly, tends to spread at an early stage, and does not …
Study reveals biological insights into triple negative breast cancer
Source:Louisiana State University Health Sciences Center From: news-medical.net Researchers at the LSU LCMC Health Cancer Center have published groundbreaking findings in NPJ Breast Cancer that sheds new light on triple-negative breast cancer (TNBC), one of the most aggressive forms of breast cancer. The National Cancer Institute (NCI)-funded study, led by Dr. Lucio Miele, Director of the LSU LCMC Health Cancer …
Scientists May Have Found a Way to Stop One of the Deadliest Breast Cancers
By Oregon Health & Science University From: scitechdaily.com Scientists at Oregon Health & Science University (OHSU) have created a new molecule that could provide a promising path forward in treating some of the most difficult cases of triple-negative breast cancer, a particularly aggressive form of the disease that currently lacks effective therapies. The findings, published in Cell Reports Medicine, detail …
Tracking RNA levels reveals new clues in triple-negative breast cancer progression
By: Jen A. Miller, Cold Spring Harbor Laboratory From: medicalxpress.com When researchers look for potential cancer therapy targets, they typically go after protein-coding genes that participate in disease progression. Disrupt them and negate whatever role they play in cancer’s development or spread. Researchers at Cold Spring Harbor Laboratory (CSHL) have also been working on another kind of target. They’re studying …
New type of immunotherapy could change the treatment plan for triple-negative breast cancer
Source: University of California – Los Angeles From: news-medical.net Triple-negative breast cancer is one of the most aggressive cancers. The name tells the story: It lacks the three main targets that make other types of breast cancers more treatable with powerful therapies. UCLA researchers have developed a novel therapy that could fundamentally change the treatment plan for this deadly disease. …
Tumor mutations of triple-negative breast cancer similar across races
By: Josh Friedman From: healio.com Key takeaways: African American women with triple-negative breast cancer had similar tumor mutational landscape as white women and Asian women. Researchers identified two pathways of disease development. Race does not significantly impact tumor mutations of triple-negative breast cancer, suggesting genetics and environmental factors are the likely reasons African American women have greater disease burden. Researchers …