From: ascopost.com Tumor cells circulating in the blood are the germ cells of breast cancer metastases. They are rare and could not be propagated in the culture dish until now. A team from the German Cancer Research Center (DKFZ), the Heidelberg Stem Cell Institute HI-STEM, and the NCT Heidelberg has now succeeded in cultivating stable tumor organoids directly from blood …
Study finds common breast cancer treatments may speed aging process
From: uclahealth.org A new study led by investigators at the UCLA Health Jonsson Comprehensive Cancer Center has revealed that common breast cancer treatments, including chemotherapy, radiation, and surgery, may accelerate the biological aging process in breast cancer survivors. The findings, published in the Journal of the National Cancer Institute, show that markers of cellular aging—such as DNA damage response, cellular …
New ADC Results Mixed in Metastatic Breast Cancer
By :Jennie Smith From: medscape.com The landscape of antibody-drug conjugates, or ADCs, continues to grow more crowded in metastatic breast cancer. Indications are expanding, new agents are emerging, combinations with other drug classes are being tested, and many patients with this disease are now receiving more than one ADC. ADCs use antibodies to bind to the surface proteins of cancer …
Which First-Line Breast Cancer Therapy Is Right for Me?
From: healthline.com Knowing where to turn next with your breast cancer treatment can be a tough decision. But understanding the different types of therapies available for metastatic breast cancer can help ensure you know what’s best for you. Hormone and targeted therapies Hormonal therapies The first-line treatment for advanced hormone receptor-positive (estrogen receptor-positive or progesterone receptor-positive) breast cancer is usually …
Managing HER2+ Early Breast Cancer: A Focus on Target Therapy
From: targetedonc.com New breast cancer diagnoses account for 31% of annual cancer diagnoses among women in the United States.1 Among those diagnoses, HER2 overexpression is observed in 25% to 30% of cases. Historically, HER2-positive (HER2+) breast cancer was considered an aggressive subtype and was associated with a poor prognosis; however, the emergence of HER2-targeted therapies such as trastuzumab has considerably …
Moffitt Researchers Identify Pathway that Controls Breast Cancer Metastasis to the Brain
From: moffitt.org Breast cancer is the second most common cause of brain metastasis, which occurs in 10% to 30% of patients with metastatic breast cancer. Breast cancer patients who develop brain metastasis have limited treatment options and poor survival. Moffitt Cancer Center researchers are working to better understand the molecular mechanisms that promote the development and progression of breast cancer …
AI may spare breast cancer patients unnecessary treatments
By: Northwestern University From: medicalxpress.com A new AI (artificial intelligence) tool may make it possible to spare breast cancer patients unnecessary chemotherapy treatments by using a more precise method of predicting their outcomes, reports a new Northwestern Medicine study. AI evaluations of patient tissues were better at predicting the future course of a patient’s disease than evaluations performed by expert …
First-Line Treatments for HER2-Positive Breast Cancer
By: Hatem Soliman, MD From: targetedonc.com Hatem Soliman, MD, medical oncologist in The Center for Women’s Oncology and assistant member of the Experimental Therapeutics Program at Moffitt Cancer Center, discusses the current first-line treatment options for patients with HER2-positive breast cancer. According to Soliman, the phase 3 CLEOPATRA study (NCT00567190) evaluated the efficacy and safety of pertuzumab (Perjeta), trastuzumab (Herceptin), …
Cell-based method can predict how breast cancer patients will respond to treatments
Source: Karolinska Institutet From: news-medical.net Researchers at Karolinska Institutet in Sweden have developed a method that should be able to predict whether a patient with breast cancer will benefit from a particular treatment or not. The cell-based method has been tested on patients with promising results, according to a study published in PNAS. Several different drugs are currently available for …
Breast cancer studies pinpoint potential new drug targets to fight resistance
By Angus Liu From: fiercebiotech.com Several types of treatments are used against breast cancer, including chemotherapy, immunotherapy and drugs that target specific genes and proteins. But not all patients respond to them, so new options for reducing treatment resistance are in high demand. Now, two research groups from Italy and the University of California, San Francisco (UCSF) have identified different mechanisms in breast …