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Gel loaded with cancer-fighting cells keeps tumors in check after surgery in mice

In Clinical Studies News by Barbara Jacoby

By: Eric Hamilton From: wisc.edu A new, biodegradable gel filled with a cocktail of immune-boosting cytokines and cancer-fighting cells staved off the growth of lingering cancer cells in mice after tumors were surgically removed. Three weeks after surgery, the tumors of mice treated with the specialized gel were roughly 60 times smaller than those of mice not given the treatment. …

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Savvy Cooperative: Paid Opportunity for People Aged 60+ with Metastatic Solid Tumor Cancer

In Paid Opportunities For The Cancer Community by Barbara Jacoby

SCREENER Requirements: Current diagnosis of metastatic cancer by a healthcare provider Proof of diagnosis will be required to participate Ages 60+ Fluent English speaker, but does not need to be the primary language U.S. resident Details: 120-minute focus group 15-minute survey From home Receive: $175 Link: https://gigs.savvy.coop/60-mets/?r=44951 Why Sign Up? Your experiences are so valuable and important to creating better …

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Alternative cancer cell fuel source targeted as therapeutic approach for breast cancer

In In The News by Barbara Jacoby

Source: The Wistar Institute From: eurekalert.org New small molecule inhibitor impairs cancer growth in preclinical models by depriving malignant cells of a critical nutrient source Scientists at The Wistar Institute characterized an inhibitor that targets acetate metabolism in cancer cells. Cancer cells use acetate metabolism to support tumor growth in conditions of low nutrient and oxygen availability. This molecule caused …

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Scientists use two powerful immunotherapies to eradicate solid tumors

In In The News by Barbara Jacoby

Source: City of Hope National Medical Center From: medicalxpress.com City of Hope scientists have combined two potent immunotherapies—an oncolytic virus and chimeric antigen receptor (CAR) T cell therapy—to target and eradicate solid tumors that are otherwise difficult to treat with CAR T therapy alone, according to a new Science Translational Medicine study. In preclinical research that could lead to a …

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Caris Life Sciences Partners with Elevation Oncology to Advance Enrollment in Phase 2 Trial of Patients with Solid Tumors Harboring NRG1 Gene Fusions

In Clinical Studies News by Barbara Jacoby

From: PR Newswire Partnership explores innovative models for real-time identification, patient referral and enrollment of patients with solid tumors with a rare gene fusion Caris Life Sciences®, a leading innovator in molecular science focused on fulfilling the promise of precision medicine, announced today that it has entered into a strategic partnership with Elevation Oncology to enhance patient enrollment practices for …

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A Novel Mechanism of Action for FS118 and the Potential to Overcome PD-(L)1 Resistance Published in Clinical Cancer Research

In Clinical Studies News by Barbara Jacoby

From: businesswire.com F-star Therapeutics Ltd., a clinical-stage biopharmaceutical company focused on transforming the lives of patients with cancer through the development of innovative tetravalent bispecific antibodies (mAb2™), today announces the publication in Clinical Cancer Research of preclinical data highlighting the potential novel mechanism of action of its wholly-owned lead clinical asset FS118, a LAG-3/PD-L1-targeting tetravalent bispecific antibody. FS118 is currently …

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Penn Researchers Identify Cancer Cell Defect Driving Resistance to CAR T Cell Therapy

In In The News by Barbara Jacoby

From: PR Newswire Study identifying mechanism that prevents cell death may guide future immunotherapy strategies Some cancer cells refuse to die, even in the face of powerful cellular immunotherapies like CAR T cell therapy, and new research from the Abramson Cancer Center of the University of Pennsylvania is shedding light on why. In a new study, researchers describe how a …

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A First-in-Human Trial Offers Hope for CAR-T in Solid Tumors

In Clinical Studies News by Barbara Jacoby

By: Julia Faith Sklar From: cancertherapyadvisor.com While chimeric antigen receptor T-cell (CAR-T) therapy has been making waves for the last few years as a novel treatment approach in cancer, the successes have remained mostly in the realm of blood cancers. This makes a first-in-human CAR-T clinical trial that targets a solid tumor growth receptor called MUC1* stand out. At the …

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Scientists show thin metal mesh loaded with T cells shrinks solid tumors

In In The News by Barbara Jacoby

By: Fred Hutchinson Cancer Research Center From: medicalxpress.com What if a metal that’s already used to repair broken bones, straighten teeth and keep arteries from clogging could also be used to stop your cancer from spreading? New findings published Dec. 9 in Nature Biomedical Engineering from scientists at Fred Hutchinson Cancer Research Center show for the first time that a …

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New York’s First Proton Therapy Center Begins Treating Patients

In In The News by Barbara Jacoby

From: PR Newswire The New York Proton Center, the first proton therapy facility to open in New York State, has begun treating patients. The center’s unique consortium of partners, comprised of three leading New York City health systems—Memorial Sloan Kettering Cancer Center (MSK), Montefiore Health System and Mount Sinai Health System—began sending patients to the state-of-the-art East Harlem facility in …