By: Charles Bankhead From: medpagetoday.com Ten years after tailored radiotherapy (RT) for breast cancer, fewer than 3% of patients had locoregional recurrences (LRR), most during the first 5 years, a Dutch registry study showed. The overall LRR of 2.9% did not differ significantly across subgroups of patients with low-, intermediate-, or high-risk disease or between the risk groups. Both the …
Novel endocrine therapy reduces the risk of breast cancer recurrence
By Denise Heady, MA From: uclahealth.org In an international study led by UCLA, researchers have shown that giredestrant, a next-generation oral selective estrogen receptor antagonist and degrader (SERD), when given as an adjuvant therapy for early-stage (1-3) hormone receptor (HR)-positive, HER2-negative breast cancer, significantly lowered the risk of the disease returning when compared with standard hormone therapies long considered the …
High risk of metastatic recurrence among young cancer patients
By Stephanie Winn From: ucdavis.edu A new study of adolescents and young adults (AYAs) with seven common cancers reveals that nearly one in ten patients diagnosed with non-metastatic disease later develop metastatic recurrence — a condition associated with significantly worse survival outcomes. Metastasis is when cancer cells spread from the initial or primary site to other parts of the body. UC Davis …
Adjuvant Endocrine/Radiation Therapy May Limit Breast Cancer Recurrence
By: Russ Conroy From: cancernetwork.com Administering endocrine therapy or radiation to patients with early-stage breast cancer in the adjuvant setting may reduce locoregional recurrence (LRR) rates, according to findings from a cohort study published in JAMA Network Open.1 Based on univariate analysis, receipt of adjuvant radiotherapy correlated with significantly lower odds of LRR (HR, 0.21; 95% CI, 0.08-0.52; P <.001), …
Real-World Data Tie Early Breast Cancer ctDNA to Recurrence, Lower OS
By: Jax DiEugenio From: oncnursingnews.com Findings from a real-world analysis using data from the Flatiron Health Research Database linked positive circulating tumor DNA (ctDNA) with lower overall survival (OS) and higher risk of recurrence in patients with early-stage breast cancer regardless of subtype, per a presentation at the 2025 American Society of Clinical Oncology Annual Meeting. Among 4,639 patients (2.4% …
Your Guide to Preventing Breast Cancer Recurrence
From: healthline.com While there’s no way to guarantee that breast cancer will never come back, medical oncologist Amy Tiersten, MD, shares how taking steps to stay healthy may also help prevent breast cancer recurrence. How important is it to stay active? Exercise has definitely been proven to reduce the risk of breast cancer recurrence. Exercising as little as 30 minutes …
Switch to Experimental Drug after Liquid Biopsy Detection of Breast Cancer Recurrence Improves Outcomes
From: cornell.edu A large prospective, randomized clinical trial in patients with advanced breast cancer has found that the use of liquid biopsy blood tests for early detection of a treatment-resistance mutation, followed by a switch to a new type of treatment, substantially extends the period of tumor control compared to standard care. The SERENA-6 study, published June 1 in the …
BCRF Investigator Discovers New Subgroups of Breast Cancer
By: Priya Malhotra, PhD From: bcrf.org Findings show structural variations in tumor cell DNA could indicate risk of recurrence or reveal tumor vulnerabilities as targets for new treatments Breast cancers are generally classified based on hormone receptor status (the presence of estrogen and progesterone receptors) and HER2 status (levels of the HER2 protein). This information can indicate how aggressive the …
Cryoablation leads to low breast cancer recurrence rates
By: Amerigo Allegretto From: auntminnie.com Ultrasound-guided cryoablation can be considered for breast cancer patients who are poor surgical candidates or who refuse surgery, suggest findings published February 3 in the Journal of Vascular and Interventional Radiology. Researchers led by Jolie Jean, MD, from New York-Presbyterian Hospital/Weill Cornell Imaging in New York found a recurrence rate of 10% when following up …
Fear of breast cancer recurrence: Survivors describe impacts and coping in study
By: Regenstrief Institute From: medicalxpress.com Breast cancer is the world’s most prevalent cancer. Although earlier detection and targeted treatment have resulted in high survival rates, many breast cancer survivors experience fear of cancer recurrence. For some survivors this fear is occasional, for others it is persistent and often debilitating. Published in Supportive Care in Cancer, a study of breast cancer …