Key Takeaways Breast cancer frequently spreads to other tissues, leading to worse outcomes for patients UC San Diego researchers have discovered a new way the body helps prevent the spread of breast cancer Results could help yield new treatment approaches and also suggest risks for people taking certain medications A study by researchers at the University of California San Diego …
Groundbreaking study maps complex interplay between cells, metabolism, and immunity in breast cancer lymph node metastasis
Source: The American Journal of Pathology From: eurekalert.org A recent integrative analysis of single-cell sequencing and single-cell spatial mapping of lymph node metastasis in breast cancer reveals novel mechanisms of the metabolic-immune interaction that drive the spread of breast cancer. The findings from the study in The American Journal of Pathology, published by Elsevier, offer novel insights into the characteristics …
Advancing Care for Brain Metastases in MBC: Where We Are Now and Where We’re Going
By: Priscilla K. Brastianos, MD From: medscape.com In the next few minutes, I’ll touch on three areas: one, how our understanding of the biology of brain metastases has evolved; two, the newer systemic agents with meaningful intracranial activity; and three, how our therapeutic approach, especially around radiation, has shifted as a result. Let’s start with the biology. Our view of …
Understanding Metastatic Breast Cancer in the Lungs
From: healthline.com Key Takeaways Metastatic breast cancer, also known as stage 4 breast cancer, occurs when breast cancer spreads to distant sites like the lungs, bones, liver, or brain, and is still treated as breast cancer regardless of the location. Treatment for metastatic breast cancer in the lungs aims to minimize symptoms, prolong life, and maintain quality of life. Options …
Mapping metastasis—how nutrient availability shapes breast cancer’s spread
By: Mass General Brigham From: medicalxpress.com Breast cancer can spread—or metastasize—to many different parts of the body, but it’s not well understood why tumors grow better in some organs than others. In a study titled “Nutrient requirements of organ-specific metastasis in breast cancer,” researchers explored whether the nutrients available in different tissues help determine where cancer spreads. Using mouse models …
For the first time, a mechanism enabling breast cancer to metastasize to the brain has been deciphered
By: Tel-Aviv University From: medicalxpress.com A large-scale international study, led by researchers from the Gray Faculty of Medical and Health Sciences at Tel Aviv University, has uncovered a mechanism that allows breast cancer to send metastases to the brain—a highly lethal occurrence for which there is currently no effective treatment. The findings could enable the development of new drugs and …
Exosomal miR-221-3p Boosts Breast Cancer Brain Metastasis
B:y Bioengineer From: bioengineer.org In a groundbreaking study published in the Journal of Translational Medicine, researchers led by Zhu and colleagues have uncovered a significant mechanism through which tumor-derived exosomal miR-221-3p plays a crucial role in breast cancer brain metastasis. The findings shed light on the interplay between tumor biology and the cerebral microenvironment, particularly how this tiny RNA fragment …
Signs Breast Cancer Has Spread to the Bones (Metastasis)
From: healthline.com Like any cancer, breast cancer can spread to other parts of the body. Breast cancer that has invaded bone can have a significant effect on quality of life, but there are treatments to help manage symptoms and slow disease progression. What is metastatic breast cancer in bones? “Metastasis” describes the spread of cancer from where it started to another part …
Study Finds Restoring Order to Dividing Cancer Cells May Prevent Metastasis
From: cornell.edu Triple negative breast cancer (TNBC) is one of the most aggressive and hardest to treat breast cancers, but a new study led by Weill Cornell Medicine suggests a way to stop it from spreading. Researchers have discovered that an enzyme called EZH2 drives TNBC cells to divide abnormally, which enables them to relocate to distant organs. The preclinical …
Diamond-based sensor advances detection of metastasized breast cancer
Source: University of Warwick From: news-medical.net University of Warwick researchers have built a new diamond-based magnetic field sensor that could be used to better find tumors through tracing magnetic fluid injected in the body. A cancer diagnosis is most problematic when cells from the tumor have metastasized (spread) to other organs. This most often occurs through the lymph nodes and …