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Breast cancer: Why metastasis spreads to the bone

In In The News by Barbara Jacoby

Source: Université de Genève From: When cancer cells break away from a primary tumor and migrate to other organs, this is called “metastatic cancer.” The organs affected by these metastases, however, depend in part on their tissue of origin. In the case of breast cancer, they usually form in the bones. In an attempt to identify what determines the organs …

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Scientists Identify Gene Driving Breast Cancer Metastasis

In In The News by Barbara Jacoby

From: clinicaloncology.com Researchers have pinpointed the gene that’s responsible for metastatic triple-negative breast cancer, according to a recently published study. Reporting in Science Translational Medicine (2022 Feb 2. doi:10.1126/scitranslmed.abf5473), the researchers detailed the role of the CECR2 gene in breast cancer metastasis. “We are constantly searching for new effective therapeutic strategies to help patients with this potentially deadly disease,” senior …

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Breast Cancer Cells Churn Out Cholesterol to Fuel Metastasis

In In The News by Barbara Jacoby

By: Alejandra Manjarrez From: the-scientist.com High levels of cholesterol in the blood, as a result of diet or disease, have been associated with an increased risk for breast cancer recurrence. Studies suggest that cancer cells may use this molecule to fuel tumor growth or to impair the immune system. But a study published this week (February 2) in Molecular Therapy …

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Arteriolar niche used by breast cancer cells to prepare for metastasis

In Clinical Studies News by Barbara Jacoby

Source: University of Alabama at Birmingham From: news-medical.net More than 43,000 American women will die from breast cancer this year. Most of those deaths will occur after the cancer has spread to other organs, a process called metastasis. This involves at least five major steps. Two early steps are invasion of the basement membrane and cell migration, and then a …

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Seeking a unique treatment for lobular breast cancer

In Clinical Studies News by Barbara Jacoby

Source: University of Colorado Anschutz Medical Campus From: sciencedaily.com Though the two main histological types of breast cancer — lobular and ductal — are treated with the same hormonal therapies, women with lobular breast cancer often have recurrence or metastasis of the disease several years after their initial treatment. In an attempt to find out why the long-term outcomes are …

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Cholesterol metabolite induces production of cancer-promoting vesicles

In Clinical Studies News by Barbara Jacoby

Source: Source:University of Illinois at Urbana-Champaign, News Bureau From sciencedaily.com Scientists studying the link between cholesterol and breast cancer report that a byproduct of cholesterol metabolism causes some cells to send out cancer-promoting signals to other cells. These signals are packaged in membrane-bound compartments called extracellular vesicles. Scientists working to understand the cellular processes linking high cholesterol to breast cancer …

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Spread of Breast Cancer Linked to Newly Discovered RNA Splicing Mechanism

In Clinical Studies News by Barbara Jacoby

By: Jeffrey Norris From: ucsf.edu What kills most people who die from cancer is not the initial tumor. It’s the intolerable disease burden on the body that arises when tumor cells continually expand their numbers after spreading to different organs. In comparison to what is already known about specific mutations that drive early-stage cancer growth – several now targeted by …

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Breast cancer study uncovers new RNA targets for treatment and diagnostics

In Clinical Studies News by Barbara Jacoby

By: Arlene Weintraub From: fiercebiotech.com Abnormalities in the genes p53 and AKT are known to promote the growth and spread of cancer, but the mechanisms behind their destructiveness are not fully understood. A research team led by Moffitt Cancer Center has made a discovery about how the activities of the two altered genes are linked—a revelation they believe could inspire …

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Activation of a distinct genetic pathway can slow the progress of metastatic breast cancer

In In The News by Barbara Jacoby

By: Olivia Newton-John Cancer Research Institute From: medicalxpress.com Metastasis, the spread of tumor cells to distant sites, is the major cause of death for people impacted by cancer. With no therapeutic cure available, it is clear that new treatments are needed urgently. In a study published today in the international journal Cancer Research, a journal of the American Association for …

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E-cadherin promotes metastasis in the most common type of breast cancer

In In The News by Barbara Jacoby

By: Amy Mone From: medicalxpress.com Researchers at the Johns Hopkins Kimmel Cancer Center discovered that a cell adhesion protein, E-cadherin, allows breast cancer cells to survive as they travel through the body and form new tumors, a process termed metastasis. Their conclusions, obtained through laboratory experiments and in mouse models, help explain how metastasis works in the most common form …