Source: Knight Therapeutics From: finance.yahoo.com Knight Therapeutics Inc. (TSX: GUD), (“Knight”) a pan-American (ex-USA) specialty pharmaceutical company, announced today that Health Canada has approved NERLYNX® (neratinib) in combination with capecitabine for the treatment of adult patients with metastatic HER2-overexpressed/amplified breast cancer, who have received two or more prior anti-HER2-based regimens in the metastatic setting. The approval was based on results …
MNT Investigates: Anti-HER2 drugs and the fight against metastatic breast cancer
From: medicalnewstoday.com HER2-positive breast cancer occurs when cancer cells have excessive amounts of a growth-promoting protein called human epidermal growth factor receptor 2 (HER2). The protein causes the tumor cells to grow and multiply, making these breast cancers aggressive and fast-spreading. About 1 in 5 women with breast cancer have HER2-positive breast cancers. Anti-HER2 drugs are therapies developed to target …
Neratinib Improve OS and CNS-Related Outcomes in Early-Stage HER2+ Breast Cancer
By: Nichole Tucker From: targetedonc.com Treatment with neratinib demonstrated a modest overall survival benefit in patients with HER2-positive breast cancer compared with placebo, according to the long-term OS and central nervous system results from the phase 3 ExteNET trial Treatment with the irreversible pan-HER inhibitor neratinib (Nerlynx) demonstrated a modest overall survival (OS) benefit in patients with HER2-positive breast cancer …
Innovations in the Treatment of HER2+ Breast Cancer
By: Sara Karlovitch From: targetedonc.com In an interview with Targeted Oncology, Komal Jhaveri, MD, FACP, a medical oncologist at Memorial Sloan Kettering Cancer Center, discusses HER2-positive metastatic breast cancer innovations, treatments, and upcoming studies. Major advances have been made in the HER2-positive breast cancer space in both the first-line and later-line settings. First, in 2015, the results from the CLEOPATRA …
Rare Patient Voice: Paid Opportunity for HER2 Positive Breast Cancer Patients
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Meisel on Managing Toxicities With T-DM1 in HER2+ Breast Cancer
By: Courtney Marabella From: onclive.com Data from the pivotal phase 3 KATHERINE (NCT01772472) has led to the addition of ado-trastuzumab emtansine (T-DM1; Kadcyla) to the HER2-positive breast cancer treatment arsenal, but the toxicities associated with the approach must be appropriately managed so that patients can continue to receive it, according to Jane L. Meisel, MD. The phase 3 KATHERINE trial …
New five-minutes treatment for breast cancer rolled out in UK by National Health Service
From: businessinsider.in A novel breast cancer treatment that takes just five minutes instead of the current two and a half hours has been launched across the UK by the National Health Service (NHS) England. The injection called Phesgo will be offered to eligible patients with HER2-positive breast cancer, undergoing chemotherapy. It takes as little as five minutes to prepare and …
Escalation and De-escalation of Therapy Beneficial in HER2+ Breast Cancer
By: Debu Tripathy, MD From: targetedonc.com Debu Tripathy, MD, discusses escalation and de-escalation of treatment in patients with HER2-positive breast cancer with HER2-targeted agents and chemotherapy. Debu Tripathy, MD, professor of medicine and chair of the Department of Breast Medical Oncology at The University of Texas MD Anderson Cancer Center, discusses escalation and de-escalation of treatment in patients with HER2-positive …
Antibody-Drug Conjugates, TKIs Drive Improved Outcomes in HER2+ Breast Cancer
By: Caroline Seymour From: onclive.com The practice-changing treatment regimens that were evaluated in the pivotal KATHERINE, HER2CLIMB, and DESTINY-Breast01 trials in women with HER2-positive breast cancer are pushing the needle forward in making this breast cancer subtype a chronic disease. The practice-changing treatment regimens that were evaluated in the pivotal KATHERINE, HER2CLIMB, and DESTINY-Breast01 trials in women with HER2-positive breast …
PHERGain II Trial Launched to Examine Chemotherapy-Free Treatment for Patients With HER2+ Breast Cancer
By: Matthew Fowler From: cancernetwork.com The PHERGain II trial will investigate the treatment of patients with early HER2-positive breast cancer using a chemotherapy-free treatment approach of trastuzumab plus pertuzumab. A clinical trial to support the use of a chemotherapy-free therapeutic approach has been launched and will aim to demonstrate that this approach is as effective as the current standard of …