From:.physiciansweekly.com For a study, researchers sought to identify the molecular processes causing Endocrine therapy resistance (ETR) using a thorough genomic investigation of breast tumors. Pre-treatment and post-treatment tumor samples from 35 estrogen receptor-positive breast cancer patients who had neoadjuvant and adjuvant endocrine therapy revealed that 3 developed intrinsic resistance, 19 acquired resistance, and 13 remained susceptible. Neoadjuvant changes in tumor …
Aromatase inhibitors better than tamoxifen at reducing the risk of breast cancer recurrence in women
By: Cancer Research UK From: medicalxpress.com A new study has shown that giving aromatase inhibitors instead of tamoxifen to premenopausal women with estrogen receptor positive (hormone-sensitive) breast cancer significantly reduces the risk of breast cancer recurrence. The results have been published today in The Lancet Oncology. For women with hormone-sensitive, operable breast cancer, giving tamoxifen treatment after surgery reduces the …
Older Age Should Not Rule Out Chemo in Breast Cancer Patients
By: Leah Lawrence, Contributing Writer From: medpagetoday.com Elderly women benefitted from undergoing adjuvant chemotherapy for their node-positive, estrogen receptor-positive breast cancer, even in the presence of multiple comorbidities, retrospective data suggested. A large study of 1,592 patients in the U.S. National Cancer Database from 2010 to 2014 showed that after adjustment for other risk factors, women ages 70 and older …
Androgen receptor stops tumor growth in the most common form of breast cancer
Source: Endocrine Society From: newswise.com Researchers say they have found a viable new therapeutic strategy for estrogen receptor-positive (ER+) breast cancer, even cancers that are resistant to current standard of care treatments. Their new preclinical study was accepted for presentation at ENDO 2020, the Endocrine Society’s annual meeting, and publication in a special supplemental section of the Journal of the …
New Compounds Kill Breast Cancer Cells and Block Tumor Growth
From: scitechdaily.com Scientists have developed new drug compounds that thwart the pro-cancer activity of FOXM1, a transcription factor that regulates the activity of dozens of genes. The new compounds suppress tumor growth in human cells and in mouse models of several types of human breast cancer. The researchers report their findings in the journal NPJ Breast Cancer. FOXM1 is a …
Scientists link 110 genes to increased risk of breast cancer
From: news-medical.net Scientists have linked 110 genes to an increased risk of breast cancer in the most comprehensive study ever to unpick the genetics of the disease. Their study used a pioneering genetic technique to analyse maps of DNA regions linked to an inherited risk of breast cancer and identify the actual genes involved in raising a woman’s risk. Researchers …