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Bone microenvironment fosters breast cancer metastatic behavior

In Clinical Studies News by Barbara Jacoby

By: Molly Chu From: bcm.edu Two studies led by Baylor College of Medicine shed new light on the unanswered question of why estrogen receptor-positive (ER+) breast cancer sometimes grows back in the bone and spreads to other tissues despite effective endocrine therapies directed at ER. Working with animal models that include patient tumor samples, the team discovered that the bone …

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Researchers Find The Gene Responsible For One of The Deadliest Breast Cancer Types

In In The News by Barbara Jacoby

By: JACINTA BOWLER From: sciencealert.com Researchers in Australia have discovered a gene responsible for a particularly aggressive type of hormone-sensitive breast cancer which has tragically low survival rates. “Hopefully this will dramatically improve the poor outcomes these patients currently suffer,” said Harry Perkins Institute of Medical Research epigeneticist Pilar Blancafort. It’s hard to overstate just how different cancers can be …

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Endoxifen Shows Promise in Treating Breast Cancer in Australian Trial, Development in the US to Accelerate

In Clinical Studies News by Barbara Jacoby

By: Ryan McDonald From: curetoday.com Results of a trial assessing endoxifen in patients with breast cancer in Australia were positive enough for the manufacturer to stop the trial before it was scheduled to be completed. The drug’s manufacturer will now accelerate its development in the U.S. Treatment with oral endoxifen during the “window of opportunity” between breast cancer diagnosis and …

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Examining resistance to breast cancer treatments

In Clinical Studies News by Barbara Jacoby

By: Molly Chiu From: bcm.edu The combination of CDK4/6 inhibitors with endocrine therapy is the standard of care for patients with estrogen receptor-positive (ER+) and HER2-negative (ER+/HER2-) metastatic breast cancer. However, a subset of patients will have tumors with intrinsic resistance to this therapy and most patients will develop resistant disease at some point during treatment. Researchers at the Lester …

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Identification of Tamoxifen Resistance Markers Can Play Role in Breast Cancer Treatment Planning

In Clinical Studies News by Barbara Jacoby

By: Rutgers Cancer Institute of New Jersey From: newswise.com One common challenge of cancer therapy is when cancer cells don’t respond to a drug that is usually able to kill or weaken them, known as treatment resistance. Tamoxifen is a drug that blocks the activity of estrogen in the breast, commonly used to treat patients with estrogen-receptor (ER) positive breast cancer. In …

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New discovery in breast cancer treatment

In In The News by Barbara Jacoby

Source: University of Adelaide From: eurekalert.org Researchers at the University of Adelaide have found new evidence about the positive role of androgens in breast cancer treatment with immediate implications for women with estrogen receptor-driven metastatic disease. Published today in Nature Medicine, the international study conducted in collaboration with the Garvan Institute of Medical Research, looked at the role of androgens …

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Yoga Therapy and Qigong for the Self-management of Pain among ER+ Breast Cancer Survivors

In In The News by Barbara Jacoby

Dr. Judi Fouladbakhsh, a nurse researcher at Oakland University (Rochester, Michigan) is seeking participants for her study exploring self-treatment of pain among women who have had Estrogen-receptor positive (ER+) breast cancer (age 21+) who report pain. Participants will receive 12-weeks of free (one-hour, one time per week) classes in Qigong/Taiji offered online by the Center for Taiji Studies. Participants will …

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Educational Session explores advances in treating ER positive breast cancer

In In The News by Barbara Jacoby

From: sabcsmeetingnews.org Estrogen receptor positive (ER+) breast cancers may represent the single largest unmet clinical need in the field. ER+ breast cancer, also called luminal breast cancer, was once considered the default type of breast cancer, said David A. Cameron, MD, MSc. “Luminal breast cancer is the commonest type of breast cancer we see worldwide, about three-quarters of all breast …

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Expert Reviews Novel Strategies in the Pipeline for the Treatment of ER-Positive Breast Cancer

In Clinical Studies News by Barbara Jacoby

By: Audrey Sternberg From: targetedonc.com Recent acceleration in the introduction of new regimens for the treatment of estrogen receptor (ER)–positive breast cancer has led to significant survival enhancement, but questions remain regarding how patients should be stratified following disease progression with these therapies.1 “In the last 7 or 8 years, we’ve seen the CDK4/6 inhibitors added to endocrine therapy and …

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Translational Research in Oncology (TRIO) Enrolls First Patient in Early Breast Cancer Phase 2 Trial

In Clinical Studies News by Barbara Jacoby

Source: Translational Research in Oncology From: globenewswire.com Translational Research in Oncology (TRIO), a global academic clinical research organization, announced today enrolment of the first patient in a Phase 2 randomized, multi-center, open-label clinical trial of GDC-9545 sponsored by F. Hoffmann-La Roche. GDC-9545 is a selective estrogen receptor degrader (SERD) that was shown to be well tolerated with encouraging tumour activity …