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Discovery of estrogen receptor ‘switches’ may aid breast cancer treatment

In In The News by Barbara Jacoby

By: Case Western Reserve University From: medicalxpress.com Researchers at Case Western Reserve University School of Medicine have discovered how specific protein regions contribute to breast cancer. Their study, published recently in Nature, focuses on what is known as the estrogen receptor, a protein linked in previous research to the development of roughly 70% of all breast tumors. Just as a …

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Navigating the Evolving Landscape of ER-Positive Metastatic Breast Cancer Treatment

In In The News by Barbara Jacoby

By:Alexandra Gerlach From: pharmacytimes.com Key Takeaways CDK4/6 inhibitors improve progression-free survival in ER+ breast cancer but increase adverse events and costs, necessitating careful treatment sequencing. PI3K inhibitors, particularly mutant-selective variants, offer potential in managing ER+ breast cancer, addressing toxicity concerns like hyperglycemia. Antibody-drug conjugates, such as trastuzumab deruxtecan, show promise in ER+ breast cancer, improving response rates but requiring careful …

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Key discovery advances fight to reduce breast cancer recurrence

In In The News by Barbara Jacoby

Source: Duke-NUS Medical School From: sciencedaily.com In looking for new ways to fight breast cancer, scientists from Duke-NUS Medical School have unmasked a surprising role of a protein generally associated with cancer growth. They have discovered that in oestrogen receptor-positive (ER+) breast cancer, this protein acts as a tumour suppressor instead. ER+ breast cancer constitutes about 80 per cent of …

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Researchers explore gut bacteria’s role in fighting breast cancer

In In The News by Barbara Jacoby

Source: Breast Cancer Now From: news-medical.net Researchers are investigating the function of gut bacteria in breast cancer, and how we could use it to fight against the disease, thanks to new funding from Breast Cancer Now. Bacteria living in our gut can affect our immune system and previous research in other cancers has shown a connection between healthier gut bacteria …

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New study advocates for de-escalating breast cancer surgery in women aged 55 and older

In In The News by Barbara Jacoby

Source: University of Pittsburgh From: news-medical.net Surgery involving sentinel lymph node biopsy for middle-aged women with estrogen receptor-positive (ER+) breast cancer may do more harm than good, according to a new study led by University of Pittsburgh and UPMC Hillman Cancer Center researchers. The team used a novel artificial intelligence pipeline developed by Realyze Intelligence, a UPMC Enterprises portfolio company, to analyze electronic …

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Scientists Find Potential “Achilles’ Heel” of Drug-Resistant Breast Cancer

In In The News by Barbara Jacoby

From: insideprecisionmedicine.com Researchers at the Baylor College of Medicine have identified a protein called PKMYT1 as a promising marker for a form of drug-resistant breast cancer, as well as a potential drug target for patients that currently face a very poor prognosis. Up to 80 percent of deaths from breast cancer are caused by estrogen receptor-alpha-positive (ER+) tumors. The standard …

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Health Canada Approves Goserelin Acetate for High-Risk, ER+ Early and Advanced Breast Cancer

In In The News by Barbara Jacoby

By: Caroline Seymour From: onclive.com Health Canada has approved a supplemental new drug application for goserelin acetate (Zoladex) 10.8 mg every 12 weeks in the management of women with estrogen receptor–positive early breast cancer with a high risk of recurrence or advanced breast cancer in the pre- and perimenopausal setting.1 The approval was based on several global trials that evaluated …

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PRMT5 Inhibition Stops Growth in Resistant Breast Cancer

In In The News by Barbara Jacoby

From: insideprecisionmedicine.com Scientists have learned that inhibiting the activity of the PRMT5 gene shuts down the growth of metastatic estrogen receptor-positive (ER+) breast cancer cells after they acquired resistance to therapy with CDK4/6 inhibitors. Doctors have increasingly treated metastatic ER+ breast cancers by combining drugs that degrade or block the estrogen receptors on breast cancer cells in combination with CDK4/6 inhibitors. While CDK4/6 …

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Zotatifin Triplet May Improve Outcomes Post–CDK4/6 Inhibition in ER+ Breast Cancer

In In The News by Barbara Jacoby

By: Courtney Flaherty From: onclive.com Despite the ever-growing landscape of therapeutics for patients with estrogen receptor (ER)–positive metastatic breast cancer beyond the first line, there is still a substantial need for effective options for those who develop resistance to standard endocrine therapies through multiple mechanisms. Due to its unique mechanism of action, adding the selective eIF4A inhibitor zotatifin (eFT226) to …

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Assessing Factors for Sequencing Therapies in ER+ Advanced Breast Cancer

In In The News by Barbara Jacoby

From: targetedonc.com In the first article of a 2-part series, Aditya Bardia, MD, MPH, leads a discussion on what factors influence sequencing treatment for patients with estrogen receptor positive advanced breast cancer. CASE SUMMARY A 62-year-old woman presented with a 6 cm right breast mass, which has been slowly growing for 1 year with palpable axillary nodes​. Her liver function test …