By: American Society for Microbiology From: medicalxpress.com A new study has shown that variation in the microbiota of the human gut impacts the pharmacokinetics of tamoxifen and thus the effectiveness of the drug. The finding, published in the journal mBio, suggests that in the future, doctors may use a simple test on a patient’s stool to check for certain bacteria …
This revolutionary breast cancer drug has saved millions of lives in its 25-year history
By: Dennis J. Slamon, MD (FEL ’82), PhD From: uclahealth.org In the early 1990s, women who were diagnosed with the HER2-positive subtype of breast cancer weren’t expected to live more than three-to-five years after diagnosis. Now, depending on the stage of the cancer at diagnosis, women with HER2-positive breast cancer have among the highest survival rates of all women with …
A breast cancer drug, susceptible to resistance, can be restored to effectiveness, researchers demonstrate
By Leslie Cantu, Medical University of South Carolina From: medicalxpress.com n a new paper published in Cancer Research, researchers at MUSC Hollings Cancer Center have shown that targeting a protein called TACC3 (transforming acidic coiled-coil containing protein 3) can restore the effectiveness of the breast cancer drug T-DM1 if the cancer cells have developed resistance T-DM1, known by the brand …
Pediatric cancer drug shows 93 percent response rate
Source: UT Southwestern Medical Center From: sciencedaily.com A first-of-its-kind drug targeting a fused gene found in many types of cancer was effective in 93 percent of pediatric patients tested, researchers at UT Southwestern’s Simmons Cancer Center announced. Most cancer drugs are targeted to specific organs or locations in the body. Larotrectinib is the first cancer drug to receive FDA breakthrough …