By: Sabrina Serani From: targetedonc.com Key Takeaways Multiomic profiling, including whole exome and transcriptome sequencing, offers prognostic value beyond standard HER2 immunohistochemistry. HER2 and ABCC1 are identified as significant transcriptomic predictors of overall survival in patients treated with T-DXd. Elevated ABCC1 expression is associated with poorer outcomes, indicating its role in resistance to T-DXd. Integrating multiomic data into clinical practice …
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