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The shape of nanoparticles in body fluids may help identify the type of cancer

In Clinical Studies News by Barbara Jacoby

Source: Nagoya University From: sciencedaily.com A recent study by scientists from Japanese universities has shown that the shape of cell-derived nanoparticles, known as “extracellular vesicles” (EVs), in body fluids could be a biomarker for identifying types of cancer. In the study, the scientists successfully measured the shape distributions of EVs derived from liver, breast, and colorectal cancer cells, showing that …

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Promising new research on aggressive breast cancer

In In The News by Barbara Jacoby

Source: University of Montreal From: eurekalert.org Better treatments of HER2-positive breast cancer are closer at hand, thanks to new research by a team led by Université de Montréal professor Jean-François Côté at the cytoskeleton organization and cell-migration research unit of the UdeM-affiliated Montreal Clinical Research Institute. Published in PNAS, the journal of the U.S. National Academy of Sciences, the new …

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New Breast Cancer Skills Program for Patients Released by American College of Surgeons

In Clinical Studies News by Barbara Jacoby

By: American College of Surgeons (ACS) From: newswise.com Breast cancer patients have access to evidence-based knowledge, checklists, and skills training to support them from surgery preparation through recovery The American College of Surgeons (ACS) Surgical Skills Patient Education Program has launched a new kit for breast cancer patients that will help guide them from diagnosis to recovery. The ACS Surgical …

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Updated recommendations for managing hereditary breast cancer

In Clinical Studies News by Barbara Jacoby

Source: Health Day From: medicalxpress.com One year of adjuvant olaparib should be offered to patients with high-risk early-stage human epidermal growth factor receptor 2 (HER2)-negative breast cancer and germline BRCA mutations after completion of (neo)adjuvant chemotherapy and local treatment, according to a rapid recommendation update published by the American Society for Clinical Oncology (ASCO). Following presentation of the results from …

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Mature Data Drive New Insights With Novel Agents in Breast Cancer

In Clinical Studies News by Barbara Jacoby

By: Caroline Seymour From: onclive.com The data with CDK4/6 inhibitors, PI3K inhibitors, antibody-drug conjugates, and PARP inhibitors in metastatic breast cancer continue to support their use in the clinic. The data with CDK4/6 inhibitors, PI3K inhibitors, antibody-drug conjugates (ADCs), and PARP inhibitors in metastatic breast cancer continue to support their use in the clinic, explained Lisa A. Carey, MD, FASCO. …

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‘Tumor avatars’ predict patients’ response to immunotherapy

In In The News by Barbara Jacoby

Source: Netherlands Cancer Institute Tumor fragments in the lab are able to predict whether the corresponding real-life patients will benefit from immunotherapy. “We’ve solved a major problem many scientists had been facing: preserving a tumors original composition and structure outside of the patient in the lab”, says cancer researcher Daniela Thommen from the Netherlands Cancer Institute. On 8 July, the …

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FDA Supports Continued Development of Oral Paclitaxel/Encequidar in Metastatic Breast Cancer

In Clinical Studies News by Barbara Jacoby

By: Kristi Rosa From: onclive.com Athenex, Inc. held a Type A meeting with the FDA to discuss the deficiencies raised in the complete response letter issued in March 2021 for the new drug application for oral paclitaxel plus encequidar in the treatment of patients with metastatic breast cancer. Athenex, Inc. held a Type A meeting with the FDA to discuss …

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Triple-negative breast cancer metastases in lungs contain more diverse cells than those in liver

In In The News by Barbara Jacoby

Source: American Association for the Advancement of Science From: eurekalert.org The site of breast cancer metastases dictates their clonal composition and reversible transcriptomic profile Metastatic tumors originating from notoriously aggressive triple-negative breast cancer that emerge in the lungs contain a more diverse array of cancer cells than those that arise in the liver, according to a new study in mice …

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TRIO Completes Enrolment for Phase 2 Giredestrant Early Breast Cancer Trial Ahead of Schedule

In Clinical Studies News by Barbara Jacoby

Source: Translational Research in Oncology From: finance.yahoo.com Translational Research in Oncology (TRIO), a global academic clinical research organization, announced today enrolment completion in coopERA Breast Cancer (WO42133/TRIO038), a Phase 2 randomized, multi-center, open-label clinical trial of giredestrant (GDC-9545) sponsored by F. Hoffmann-La Roche. This comes shortly after completion of the planned study interim analysis provided encouraging results and supported continuation …

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Naoto Ueno, MD, PhD, on Best Practices for Palliative Care for Patients With Metastatic Breast Cancer

In In The News by Barbara Jacoby

By: Jeff Minerd From: medpagetoday.com “Practical and specific” guide for general oncologists about providing supportive care when specialists are unavailable Palliative care specialists are not always available in everyday practice, and it often falls to general oncologists to assess palliative care needs. Oncologists must therefore be familiar with the requirements and priorities for primary supportive care — a topic recently …