By: Molly Chiu From: bcm.ed oss of one copy of the DNA Ligase I (LIG1) gene in triple-negative breast cancers (TNBC) with TP53 mutations confers resistance to chemotherapy, but researchers at Baylor College of Medicine and collaborating institutions have identified a vulnerability in these cells and used it to their advantage. The team identified underlying molecular mechanisms of platinum resistance …
Researchers uncover how breast cancer cells become resistant to therapy
By: Molly Chiu From: bcm.edu About one-fourth of recurrent estrogen receptor-positive (ER+) breast cancers lose ER expression, which renders them resistant to endocrine therapy and able to grow uncontrolled. A team of researchers at Baylor College of Medicine has investigated how these cells lose their ER, and in the current study published in the Proceedings of the National Academy of …
Drug doubles down on bone cancer, metastasis
Source: rice.edu and bcm.edu From: rice.edu Rice, Baylor’s ‘BonTarg’ combines breast cancer drug with bone-targeting antibody Bone cancer is hard to treat and prone to metastasis. Research teams at Rice University and Baylor College of Medicine have a new strategy to attack it. Chemist Han Xiao at Rice and biologist Xiang Zhang at Baylor and their labs have developed an …
Breast cancer study uncovers new RNA targets for treatment and diagnostics
By: Arlene Weintraub From: fiercebiotech.com Abnormalities in the genes p53 and AKT are known to promote the growth and spread of cancer, but the mechanisms behind their destructiveness are not fully understood. A research team led by Moffitt Cancer Center has made a discovery about how the activities of the two altered genes are linked—a revelation they believe could inspire …
New Baylor Study Will Train AI to Assist Breast Cancer Surgery
By: Samantha McGrail From: hitinfrastructure.com Researchers at Baylor College of Medicine will enroll patients in a study, ATLAS AI, which will use a high-resolution imaging system to collect images of breast tumors in order to develop artificial intelligence (AI) that can help with breast cancer surgery, according to a recent press release. ATLAS AI will leverage Perimeter Medical Imaging’s OTIS …
Protein AKAP8 suppresses breast cancer metastasis
By: Molly Chiu From: bcm.edu A protein naturally produced in the body has been found to suppress breast cancer metastasis in animal models of human tumors. Researchers led by Baylor College of Medicine also found that high levels of this protein, AKAP8, predicts a better survival for breast cancer patients. The findings, in the current edition of the journal Nature …
Baylor recruiting participants for cervical cancer clinical trial
From: Molly Chiu From: bcm.edu Researchers at Baylor College of Medicine are recruiting volunteers for a clinical trial to test an oral targeted therapy for patients with metastatic cervical cancer. They are looking for women age 18 and older with stage IV cervical cancer who have completed three to six treatments of carbo/taxol with clinical evidence of complete or partial …
Discovery of novel mechanism by which certain breast cancers can metastasize
By: Dr. Ananya Mandal, MD From: news-medical.net Researchers from the Baylor College of Medicine and Harvard Medical School have found a novel mechanism to explain the resistance of certain breast cancers that spread in the major organs of the body. They hope that this would help develop new therapeutic strategies to treat the cancer. The study titled, “FOXA1 upregulation promotes …
Survivors of Childhood Brain Tumors Experience Lasting Cognitive and Socioeconomic Burdens
Source: Wiley Research News From: prnewswire.com Survivors of childhood brain tumors who received radiotherapy and were very young at the time of diagnosis may experience cognitive and socioeconomic burdens decades after treatment, according to a study published early online in CANCER, a peer-reviewed journal of the American Cancer Society. Interventions such as cognitive therapies and educational and occupational services may …