Danish Study: Higher Body Mass Index During Childhood may result in Lower Risk of Breast Cancer

In In The News by Barbara Jacoby

By: Danielle Garcia

From: oncozine.com

The results of a study of more than 173,000 women in Denmark, presented at the European Association for the Study of Obesity (EASO) 28th European Congress on Obesity, Online, May 10 – 13, 2021, suggests that girls with a higher body mass index (BMI) during childhood are less likely than their peers with a lower BMI to develop breast cancer as adults, both before and after the menopause. [1]lo

The study received funding from the World Cancer Research Fund.

The findings contrast with those for adult BMI, which indicates that women who gain weight after menopause have an increased risk of postmenopausal breast cancer. While the authors are unsure why children with a higher BMI appear to be protected against breast cancer, they caution that having overweight or obese can have many adverse impacts on general health.

“Our results suggest that having a higher BMI during childhood may lower your risk of breast cancer both before and after menopause. But we must be really clear that weight gain should not be considered as a way of preventing breast cancer”, says lead author Dorthe Corfitzen Pedersen, from Bispebjerg and Frederiksberg Hospital and a Ph.D. student in the research group of Life Course Epidemiology of Growth and Health, Section of Epidemiology who also has a master’s degree in Human Nutrition from the University of Copenhagen, Denmark.

“There are so many health risks linked with having overweight or obesity, it is vital for women to maintain a healthy weight throughout their lives.”

Breast cancer is the most common cancer in women, with around 55,000 women diagnosed every year in the UK alone, and almost 1 in 5 cases developing in those under the age of 50. Previous research has established a link between increased BMI in adult women and a lower risk of breast cancer before menopause, but an increased risk after menopause.

Although a high childhood BMI may be protective against the risk of overall breast cancer, past studies had not been large enough to investigate the link by type menopausal status.

To provide more evidence, Danish researchers analyzed data for 173,373 women from the Copenhagen School Health Records Register born between 1930 and 1996 (aged 25 to 91 years now) who had information on height and weight measured at annual school health examinations from ages 7 to 13 years. Cases of breast cancer were identified by linking with the Danish Cancer Registry.

During an average of 33 years of follow-up, 4,051 women were diagnosed with breast cancer before menopause (at 55 years of age or younger), and 5,942 women after menopause (after age 55 years).

The analyses suggest “inverse associations” between childhood BMI and breast cancer risk before and after menopause, which means that breast cancer risks decreased as BMI increased. For example, when comparing two 7-year-old girls with an average height and one z-score difference in BMI (equivalent to 2.4 kg), the girl with the highest BMI had a 7% lower risk of developing pre-menopausal breast cancer and a 10% lower risk of developing postmenopausal breast cancer than the girl with the lower BMI.

The authors say that further studies are needed to uncover the mechanisms underlying these associations. They acknowledge that the findings are associations only, so no conclusions can be drawn about cause and effect, and point to several limitations, including that the study used BMI as a marker of fat mass, but children with the same BMI can have different body fat distributions and overall levels of body fat.

[1] Pedersen, D.C.,Jensen, B.W., Tjønneland, A., Andersen, Z, Mellemkjaer, L., Bjerregaard, L., Aarestrup, J, Baker, J. L. Body mass index in childhood and its associations with risks of pre- and post-menopausal breast cancer. Abstract TS02.04 Presented at: European Association for the Study of Obesity (EASO) 28th European Congress on Obesity, held May 10 – 13, 2021.