By: By Dr. Liji Thomas, MD From: news-medical.net Breast cancer causes 670,000 deaths each year, according to the World Health Organization (WHO). About three-fourths of these cancers express estrogen receptors (ER), and these are primarily treated with antiestrogens in the adjuvant and metastatic settings. A recent paper in Nature Cancer reported on the PIONEER study, which examined the effect of …
Study identifies PUF60 as a critical vulnerability in triple negative breast cancer
Source: University of California – San Diego From: news-medical.net Researchers at University of California San Diego have identified a previously unrecognized treatment target for triple‑negative breast cancer (TNBC), the most aggressive subtype of breast cancer. Their new study reveals that a protein called PUF60 plays an essential role in helping TNBC cells grow and survive by controlling how key genes …
Advancing Care for Brain Metastases in MBC: Where We Are Now and Where We’re Going
By: Priscilla K. Brastianos, MD From: medscape.com In the next few minutes, I’ll touch on three areas: one, how our understanding of the biology of brain metastases has evolved; two, the newer systemic agents with meaningful intracranial activity; and three, how our therapeutic approach, especially around radiation, has shifted as a result. Let’s start with the biology. Our view of …
ACS reports milestone increases in cancer survival
By: Amerigo Allegretto From: auntminnie.com Cancer mortality rates continue to decline, with five-year survival rates reaching milestones, according to the American Cancer Society’s (ACS) annual cancer statistics report released on January 13. The ACS reported that about seven in 10 people who were diagnosed with cancer are reaching the five-year survival milestone, up from less than half of people in …
Understanding Metastatic Breast Cancer in the Lungs
From: healthline.com Key Takeaways Metastatic breast cancer, also known as stage 4 breast cancer, occurs when breast cancer spreads to distant sites like the lungs, bones, liver, or brain, and is still treated as breast cancer regardless of the location. Treatment for metastatic breast cancer in the lungs aims to minimize symptoms, prolong life, and maintain quality of life. Options …
Mapping metastasis—how nutrient availability shapes breast cancer’s spread
By: Mass General Brigham From: medicalxpress.com Breast cancer can spread—or metastasize—to many different parts of the body, but it’s not well understood why tumors grow better in some organs than others. In a study titled “Nutrient requirements of organ-specific metastasis in breast cancer,” researchers explored whether the nutrients available in different tissues help determine where cancer spreads. Using mouse models …
What Does It Mean to Have HER2-Negative Breast Cancer?
From; Healthline.com Human epidermal growth factor receptor 2 (HER2) is a protein that’s found on the surface of breast cells. Its normal function is to promote cellular growth and division. Some breast cancers have higher-than-normal levels of HER2 protein receptors. These are called HER2-positive breast cancers. However, only a low percentage of breast cancers are HER2-positive. Most breast cancers are …
FDA OKs Study Progression of (Z)-Endoxifen in Metastatic Breast Cancer
By: Roman Fabbricatore From: cancernetwork.com The FDA issued a “Study May Proceed” letter for a new study investigating oral (Z)-endoxifen in patients with metastatic breast cancer, according to a news release from the developer, Atossa Therapeutics.1 The subject of a recent investigational new drug (IND) application, the ongoing study aims to provide a new therapeutic strategy for patients with estrogen …
For the first time, a mechanism enabling breast cancer to metastasize to the brain has been deciphered
By: Tel-Aviv University From: medicalxpress.com A large-scale international study, led by researchers from the Gray Faculty of Medical and Health Sciences at Tel Aviv University, has uncovered a mechanism that allows breast cancer to send metastases to the brain—a highly lethal occurrence for which there is currently no effective treatment. The findings could enable the development of new drugs and …
Most women positive toward receiving breast cancer risk communication
By: Amerigo Allegretto From: auntminnie.com Most women have positive attitudes toward learning their breast cancer risk category and screening plan, according to research published December 29 in Clinical Breast Cancer. A team led by Jennifer Brooks, PhD, from the University of Toronto in Ontario, Canada, reported that over seven in 10 women perceive easing worry as an advantage of learning …