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The Alcohol and Breast Cancer Connection

In In The News by Barbara Jacoby

From: bcrf.org Did you know alcohol is a carcinogen? If not, you’re far from alone. For years, the national dialog around alcohol use has centered around wine’s purported heart health benefits, thanks to muddied public health and media messaging and industry lobbying. A study in the journal Cancer Epidemiology, Biomarkers & Prevention found that more than half of adults don’t …

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Ribociclib Plus Endocrine Therapy Demonstrates PFS Advantage in HR+/HER2– Advanced Breast Cancer

In In The News by Barbara Jacoby

By: Kyle Doherty From: onclive.com Frontline treatment with ribociclib (Kisqali) in combination with endocrine therapy displayed a significant progression-free survival (PFS) benefit with superior tolerability vs combination chemotherapy in patients with clinically aggressive hormone receptor–positive, HER2-negative advanced breast cancer, according to findings from the phase 2 RIGHT Choice trial (NCT03839823) published in the Journal of Clinical Oncology. At a median …

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New way to kill cancer cells could lead to longer lasting protection for people with breast cancer

In In The News by Barbara Jacoby

From: icr.ac.uk Killing breast cancer cells in a way that trains the immune system to recognise and destroy residual cancer cells could offer longer lasting protection to people with the disease. The early-stage discovery published in the journal Immunity, shows that by causing cancer cells to undergo a process called immunogenic cell death, the immune system is switched on and …

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ASTRO guideline on radiation therapy for bone mets emphasizes patient-centered care

In In The News by Barbara Jacoby

he American Society for Radiation Oncology (ASTRO) published yesterday an updated clinical guideline that details best practices for treating patients who have symptomatic bone metastases and ways to improve their quality of life. The guideline is available as a free access article in Practical Radiation Oncology, ASTRO’s clinical practice journal. Many types of cancer can spread to a patient’s skeletal …

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Tailored Drug Targets Aggressive Breast Cancer

In In The News by Barbara Jacoby

From: insideprecisionmedicine.com Scientists from King’s College London have made a significant breakthrough in the treatment of aggressive breast cancer by developing a tailored drug that exploits the cancer cells’ weaknesses. This innovative approach, published in Clinical Cancer Research and funded by Breast Cancer Now, offers new hope for patients with triple-negative breast cancer, a particularly challenging form of the disease. …

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New AI tool to detect possible metastatic breast cancer

In In The News by Barbara Jacoby

From: utsouthwestern.edu Researchers at UT Southwestern Medical Center have developed a novel artificial intelligence (AI) model to improve the detection of breast cancer metastasis, which could reduce the need for needle or surgical biopsies. The noninvasive model uses standard magnetic resonance imaging (MRI), paired with machine learning AI, to detect axillary metastasis – the presence of cancer cells in the …

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Real-World Study Sheds Light on Treatment Sequences and Second-Line Outcomes in HER2+ Breast Cancer

In In The News by Barbara Jacoby

By: Megan Hollasch From: onclive.com A real-world study published in the International Journal of Clinical Oncology demonstrated that most patients with HER2-positive metastatic breast cancer discontinued second-line treatment in US community practices, which study authors noted underscores the need for timely second-line treatment. Findings from the retrospective cohort revealed that at a median follow-up of 22 months (IQR, 13-37) from …

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CDH1 Linked With New Hereditary Breast Cancer Syndrome

In In The News by Barbara Jacoby

By: Cristina Ferrario From: medscape.com BRCA is no longer the only gene that identifies hereditary breast cancer (BC) syndromes. Pathogenic variants of CDH1 identify a form of hereditary lobular BC (HLBC) that is unrelated to the better-known breast-ovarian syndrome linked to alterations in BRCA1 and BRCA2, according to a recent all-Italian study published in JAMA Network Open. “Pathogenic or likely pathogenic …

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Chemotherapy linked to physical decline in older women with high-risk breast cancer

In In The News by Barbara Jacoby

Source: University of California – Los Angeles Health Sciences From: news-medical.net A UCLA-led study suggests women who are 65 years old or older with high-risk breast cancer and are treated with chemotherapy are more likely to develop a substantial decline in physical function. The study, published in a special issue of the Journal of Cancer Survivorship, found over 30% of older …

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More chemo response details needed in breast MRI reporting

In In The News by Barbara Jacoby

By: Amerigo Allegretto From: auntminnie.com Several neoadjuvant chemotherapy response characteristics are often left out of breast MRI reports, suggest findings presented May 7 at the American Roentgen Ray Society (ARRS) annual meeting. In a talk delivered at the conference, Sheida Ebrahimi, MD, from the University of California, San Diego presented her team’s study, which showed that little to no reports …