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THE UNDERSTUDIED CONSEQUENCES OF PERIPHERAL NEUROPATHY AFTER CHEMOTHERAPY

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In two papers published in the Journal of the National Cancer Institute researchers from UC Davis, UCLA and other institutions have found that peripheral neuropathy, which causes pain, numbness, and tingling in hands and/or feet, can bother early-stage breast cancer patients years after completing chemotherapy. In addition, a systematic literature review found only a handful of studies that tracked long-term …

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Study could find ways to block cancer growth

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By: Kathy Keatley Garvey From: record-bee.com Newly published UC Davis research characterizing specific mechanisms involved in blocking angiogenesis, or the formation new blood vessels, has the potential to block cancer growth and target other diseases, researchers said. Earlier research by the Judah Folkman laboratory of Harvard Medical School showed that cutting off blood vessels that feed a cancerous tumor can …

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EARLY CANCER DEATHS LINKED TO BEING SINGLE, LIVING IN A POOR NEIGHBORHOOD

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Patients in California hospitals were more likely to die within 60 days of being diagnosed with acute myeloid leukemia – a cancer of the blood and bone marrow – if they were unmarried, lived in a less-affluent neighborhood or lacked health insurance. The UC Davis study also found that patients treated at a National Cancer Institute (NCI)-designated cancer center were …

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SECOND CANCERS DEADLIER IN YOUNG PATIENTS

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Second cancers in children and adolescents and young adults (AYA) are far deadlier than they are in older adults and may partially account for the relatively poor outcomes of cancer patients ages 15-39 overall, a new study by UC Davis researchers has found. The study also found that survival after almost all types of cancer is much higher when the …

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MANY LATE-STAGE LUNG CANCER PATIENTS DO NOT GET TREATMENT

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A national study by researchers at UC Davis Comprehensive Cancer Center has found that a significant number of lung cancer patients are not receiving treatment. Based on data between 1998 and 2012 from the National Cancer Database, 21 percent of patients (190,539) with non-small cell lung cancer (NSCLC) received no specific cancer treatment, such as chemotherapy, radiotherapy or surgery. Many …

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Faulty DNA error correction genes set stage for familial gastric cancer

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A large team of researchers from UC Davis and several European and Latin American institutions have identified genetic variations that contribute to familial gastric cancer. These inherited mutations, which affect the PALB2, BRCA1 and RAD51C genes and have been implicated in other cancer types, impair a critical DNA repair mechanism called homologous recombination. These findings could improve preventive care, as …

Breast cancer patient finds new hope with potentially revolutionary treatment

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Source: City of Hope From: news-medical.net City of Hope patient Susan Young has had a remarkable response to a potentially revolutionary new treatment, a combination of the p53 cancer vaccine and a drug that blocks a specific cancer-aiding protein. The 69-year-old came to City of Hope in August 2016 from UC Davis with advanced triple-negative breast cancer that had metastasized …

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Lung cancer patients who have surgery live longer

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But fewer patients with advanced lung cancer are having surgery. Patients with late-stage, non-small cell lung cancer (NSCLC) who have surgery have better survival rates than those who don’t, but fewer of these patients are undergoing surgery, UC Davis researchers have found. Published today in The Annals of Thoracic Surgery, the study raises an important question: Why aren’t more patients …

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Miglioretti awarded $7.5 million to evaluate supplemental breast imaging

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Diana Miglioretti, UC Davis dean’s professor of biostatistics and an internationally recognized breast cancer screening expert, has received $7.5 million to determine the effectiveness of two supplemental breast screening and diagnostic workup strategies — digital breast tomosynthesis (3D mammography) and magnetic resonance imaging (MRI) — used with mammography for cancer detection. Miglioretti’s team also will work to determine whether effectiveness …

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TUMOR SUPPRESSOR LRIG1 CONTROLS BREAST CANCER AGGRESSION AND INVASION

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From: UC Davis Comprehensive Cancer Center Protein blocks dangerous epithelial-to-mesenchymal transition Researchers at UC Davis have shown that the protein LRIG1 reduces breast cancer invasion and could potentially help control metastasis. Using aggressive basal-like breast cancer cell lines, the scientists found that restoring LRIG1 expression reduced these cells’ growth and invasiveness. The findings provide strong evidence that LRIG1 could be …