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How destroying a tumor promoter could lead to new cancer treatments

In In The News by Barbara Jacoby

By: Catharine Paddock PhD From: medicalnewstoday.com Scientists have cracked a cell mechanism that drives tumor formation in most types of cancer. This finding could lead to much-needed new therapies for cancer, including the hard-to-treat triple-negative breast cancer. The discovery concerns the molecular activity of the tumor suppressor protein p53. This protein sits inside the nucleus of the cell and protects …

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Tumor-suppressing protein actually promotes cancer

In In The News by Barbara Jacoby

Source: Tulane University From: sciencedaily.com Tulane University researchers have discovered that the protein PHLDB3, thought to be a potential tumor suppressor, actually allows cancer cells to thrive in pancreatic, prostate, colon, breast, lung, and other common cancers. The discovery could explain how cancer is able to overcome p53 — a key tumor-suppressing protein. The findings, recently published in Nature Communications, …

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TUMOR SUPPRESSOR LRIG1 CONTROLS BREAST CANCER AGGRESSION AND INVASION

In In The News by Barbara Jacoby

From: UC Davis Comprehensive Cancer Center Protein blocks dangerous epithelial-to-mesenchymal transition Researchers at UC Davis have shown that the protein LRIG1 reduces breast cancer invasion and could potentially help control metastasis. Using aggressive basal-like breast cancer cell lines, the scientists found that restoring LRIG1 expression reduced these cells’ growth and invasiveness. The findings provide strong evidence that LRIG1 could be …