By: Amanda Brink, DNP, APRN, FNP-BC, AOCNP From: cancernursingtoday.com Triple-negative breast cancer (TNBC) remains a highly aggressive subtype with limited targeted treatment options. Oncology nurses care for patients who often face significant physical, emotional, and psychosocial challenges, including treatment-related side effects and psychological distress. In addition to pharmacologic management of these symptoms, nurses and patients frequently turn to integrative approaches …
The Promise of ctDNA in Triple-Negative Breast Cancer
By: Amanda Brink, DNP, APRN, FNP-BC, AOCNP From: cancernursingtoday.com Patients and providers alike are becoming increasingly interested in the role of circulating tumor DNA (ctDNA) in predicting response to cancer treatment and assessing the risk of relapse. Although ctDNA is not yet routinely used in clinical practice for most patients with breast cancer, it holds significant promise, particularly in aggressive …
Revolutionizing Triple-Negative Breast Cancer Treatment: A Safer Path Forward
By: Sabrina Serani From: targetedonc.com Triple-negative breast cancer (TNBC) is a notoriously aggressive form of cancer, often requiring intense and highly toxic treatment regimens. The current standard of care frequently involves anthracyclines, a class of chemotherapy drugs known for their severe adverse effects, including secondary blood cancers like leukemia and irreversible heart failure. This urgent unmet need for effective yet …
MRI predicts treatment response for triple-negative breast cancer
By: Amerigo Allegretto From: auntminnie.com Post-treatment MRI can accurately predict treatment response for early triple-negative breast cancer, according to research published July 1 in Radiology. A team led by Toulsie Ramtohul, MD, from the Curie Institute in Paris, France, found that their logistic regression model, which used radiologic complete response, nodal involvement, and Ki-67 indexing, achieved high predictive value for complete …
How Triple-Negative Breast Cancer Cells Metastasize
By: Greg Glasgow From: cuanschutz.edu Newly published research led by Heide Ford, PhD, associate director of basic research at the University of Colorado Cancer Center, sheds new light on how triple-negative breast cancer cells evade immune surveillance to spread to other sites in the body. In a paper that came out in May in the journal Science Advances, Ford and her co-investigators show that a family …
ADC Combination Outperforms Standard Treatment of Advanced Triple-Negative Breast Cancer
From: dana-farber.org In patients with an aggressive form of breast cancer, treatment with the antibody-drug conjugate sacituzumab govitecan plus pembrolizumab resulted in durable responses with improved progression free survival compared to the current standard treatment. The ASCENT-04 study presented today by Dana-Farber Cancer Institute investigators evaluated patients receiving their first treatment for advanced or metastatic triple negative breast cancer that …
Omega-6 Fatty Acid Promotes the Growth of an Aggressive Type of Breast Cancer
From: cornell.edu Linoleic acid, an omega-6 fatty acid found in seed oils such as soybean and safflower oil, and animal products including pork and eggs, specifically enhances the growth of the hard-to-treat “triple negative” breast cancer subtype, according to a preclinical study led by Weill Cornell Medicine investigators. The discovery could lead to new dietary and pharmaceutical strategies against breast …
Novel radiotracer identifies biomarker for triple-negative breast cancer
By: Society of Nuclear Medicine and Molecular Imaging From: medicalxpress.com A new PET radiotracer can effectively visualize Nectin-4, an emerging biomarker found in triple-negative breast cancer (TNBC). According to research published in the March issue of The Journal of Nuclear Medicine, the PET tracer has the potential to play a critical role in the diagnosis, treatment, and monitoring of this …
Immunotherapies Spark Excitement in Triple-Negative Breast Cancer Treatment
By: Tony Berberabe, MPH From: targetedonc.com THE USE OF IMMUNOTHERAPY approaches in triple-negative breast cancer (TNBC) has resulted in diverse breakthroughs that leverage immune checkpoint inhibitors (ICIs). Expanded use of ICIs has led to the identification of different molecular subtypes that can help develop individualized treatment plans. Investigators in numerous trials are exploring immunotherapy in combination with existing treatment modalities …
BCRF Research Identifies Immune Cell Changes in Triple-Negative Breast Cancers
By: Priya Malhotra, PhD From: bcrf.org Findings may help explain why immunotherapies aren’t effective in certain patients with TNBC BCRF investigator Dr. Xiang Zhang and his colleagues are examining the crosstalk between a breast tumor and the body’s immune system to understand why some cancers do not respond to treatment. He and his team recently published results in Nature Cell …