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Roche’s ipatasertib combo shows early promise in triple-negative breast cancer

In Clinical Trials by Barbara Jacoby

By: Anna Smith From: pharmatimes.com Roche has announced results from a Phase Ib trial assessing its AKT-inhibitor ipatasertib, Tecentriq (atezolizumab) and chemotherapy in triple-negative breast cancer (TNBC), showing a 73% overall response rate irrespective of PD-L1 status. Out of the first 26 subjects in the study, 19 had confirmed responses.The trial consisted of two arms; ipatasertib in combination with Tecentriq and …

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Targeting triple-negative breast cancer with new drug design

In In The News by Barbara Jacoby

By: Laura Castañón, Northeastern University From: medicalxpress.com The type of breast cancer most likely to affect young people and African Americans is also one of the most aggressive and difficult to treat. Triple-negative breast cancer, which represents about 20 percent of all breast cancer cases, is named for its lack of three common hormone receptors. Since targeted breast cancer treatments …

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Public domain antibiotic found highly effective against triple-negative breast cancer

In In The News by Barbara Jacoby

Source: University of Geneva From: medicalxpress.com Of the three major subtypes of breast cancer, triple negative is the most lethal. Half of all breast cancer deaths are attributed to it, whereas it accounts for only about 15 percent of incidences of breast cancer. And unlike other breast cancers, it is resistant to most existing therapies. By studying the properties of …

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Estrogen May Trigger Brain Metastasis in Triple-negative Breast Cancer, Study Shows

In In The News by Barbara Jacoby

By: Ana Pena From: breastcancer-news.com Estradiol, a type of estrogen and the major female hormone, may drive the spread of cancer to the brain in women with triple-negative breast cancer (TNBC), a study in mice and human cells reports. Researchers identified a chain of molecular events triggered by estradiol that appears to be behind tumor cells’ ability to form brain …

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Triple-negative breast cancer: Recurrence and survival rates

In In The News by Barbara Jacoby

By: Jenna Fletcher From: medicalnewstoday.com Triple-negative breast cancer is an aggressive form of the disease. To understand it, a person should know about the other types of breast cancer. Some breast cancers have receptor cells that respond to hormones. There are three main types of receptors: estrogen receptor progesterone receptor human epidermal growth factor receptor 2 Doctors diagnose breast cancer …

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Antipsychotic Drug Blocks Triple-Negative Breast Cancer Growth

In Clinical Trials by Barbara Jacoby

From: genengnews.com The results of studies by a team of scientists in the U.K. and Spain suggest that the commonly used antipsychotic drug Pimozide could offer a new treatment approach to the most hard to treat form of breast cancer, and potentially for lung cancer. The research, headed by Mohamed El-Tanani, Ph.D., professor of molecular pathology and cancer therapeutics at …

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A new type of breast cancer treatment could help stop the spread of a highly aggressive form of the disease

In In The News by Barbara Jacoby

By: Julia Naftulin From: thisisinsider.com Researchers from Princeton University discovered a new breast cancer treatment method that could stop the spread of an especially aggressive form of the disease called triple-negative breast cancer. The new method uses a naturally occurring protein called Tingal1 to block the passageways in which triple-negative breast cancer could spread to other areas of the body. …

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Aggressive breast cancer cells hijack natural stress protector to thrive

In In The News by Barbara Jacoby

Source: Medical College of Georgia at Augusta University From: sciencedaily.com A member of a protein family known for protecting our cells also protects cancer cells in aggressive, metastatic breast cancer, scientists report. Induction of heat shock protein 70, or HSP70, — which protects cells from stress — appears to be a key difference between difficult-to-treat triple negative breast cancer and …

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A master switch controls aggressive breast cancer

In In The News by Barbara Jacoby

Salk scientists who discovered that aggressive breast cancer reprises pathways found in fetal cells have identified genetic master switch for process A team at the Salk Institute has identified a master switch that appears to control the dynamic behavior of tumor cells that makes some aggressive cancers so difficult to treat. The gene Sox10 directly controls the growth and invasion …

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New approach for hard-to-treat BRCA breast cancer shrinks tumours twice as fast

In In The News by Barbara Jacoby

By: Henry Bodkin From: telegraph.co.uk Scientists have expressed optimism for women with hard-to-treat breast cancer after a new chemotherapy regime proved it can shrink tumours twice as fast as normal methods. Women with aggressive “triple-negative” disease fare much better on a non-standard chemotherapy drug if they have inherited BRCA gene mutations, the results of a trial showed. Currently most patients with this type of breast cancer, …