By: Quincy Attobrah From: oncnursingnews.com Datopotamab deruxtecan (Datroway) demonstrated improved progression-free survival (PFS) and overall survival (OS) compared with standard chemotherapy in patients with previously untreated, advanced triple-negative breast cancer (TNBC) who were not eligible for immunotherapy, according to results from the phase 3 TROPION-Breast02 trial. The findings, published in Annals of Oncology, address a significant unmet need in TNBC, …
Radiation may spark tissue changes that help triple-negative breast cancer return
By: Vanderbilt University From; medicalxpress.com While radiation therapy is an effective tool to destroy cancer cells, a new study from Vanderbilt researchers suggests that in an aggressive form of breast cancer, it may also trigger a protective cellular response that may explain why our current therapies fail some patients. The research was led by Marjan Rafat, assistant professor of chemical …
Pumitamig Plus Chemo Drives Strong Responses Across PD-L1 Subgroups of Metastatic TNBC
By: Ashling Wahner From: onclive.com The VEGF/PD-L1–directed bispecific antibody pumitamig (BNT327/BMS986545) has been shown to restore immune activity and improve outcomes in patients with metastatic triple-negative breast cancer (TNBC), showing strong response rates even in patients with a PD-L1 combined positive score (CPS) lower than 10, according to Sarah Sammons, MD. Previously, data from a phase 1b/2 trial (NCT05918133) conducted …
A new triple negative breast cancer target: Why HORMAD1 could guide treatment choices
By: Institute of Cancer Research From: medicalxpress.com A gene that is typically active only in reproductive cells may hold the key to new treatments for triple negative breast cancer, according to new research published in the journal Nature Communications. Scientists from the Breast Cancer Now Toby Robins Research Center at The Institute of Cancer Research, London (ICR) and the Breast …
New approach better predicts chemotherapy response in patients with triple-negative breast cancer
Source: University of Texas M. D. Anderson Cancer Center From: news-medical.net Researchers at The University of Texas MD Anderson Cancer Center have developed a new computational approach designed to better account for changes in gene expression within tumors relative to their unique microenvironments. This approach outperformed current methods for predicting chemotherapy response in patients with triple-negative breast cancer (TNBC). The …
Triple negative breast cancer cells use new strategy to boost metastatic ability
Source: Baylor College of Medicine From: news-medical.net Researchers at Baylor College of Medicine have uncovered a strategy that triple negative breast cancer (TNBC) cells use to boost their ability to metastasize, or spread to other organs. Metastasis is the leading cause of cancer-related deaths and scientists are investigating ways to prevent it. These findings, published in Nature Communications, highlight new …
Purdue researchers discover new therapeutic target for triple-negative breast cancer
Source: Purdue University From: news-medical.net A Purdue University team led by Kyle Cottrell has discovered a new therapeutic target for triple-negative breast cancer. Cottrell, biochemistry graduate student Addison Young and their co-authors describe the discovery in the journal RNA. The laboratory research spotlights double-stranded ribonucleic acid (dsRNA)-binding proteins. “Generally, people are taught in high school biology that RNA is single-stranded. …
Study identifies PUF60 as a critical vulnerability in triple negative breast cancer
Source: University of California – San Diego From: news-medical.net Researchers at University of California San Diego have identified a previously unrecognized treatment target for triple‑negative breast cancer (TNBC), the most aggressive subtype of breast cancer. Their new study reveals that a protein called PUF60 plays an essential role in helping TNBC cells grow and survive by controlling how key genes …
New Antibody Halts One of the Deadliest Breast Cancers
By: Medical University of South Carolina From: scitechdaily.com Scientists have uncovered a powerful new antibody that disrupts a key protein helping triple-negative breast cancer survive and evade immunity. Triple-negative breast cancer (TNBC) is considered one of the most aggressive and difficult forms of breast cancer to treat. It grows rapidly, tends to spread at an early stage, and does not …
Study reveals biological insights into triple negative breast cancer
Source:Louisiana State University Health Sciences Center From: news-medical.net Researchers at the LSU LCMC Health Cancer Center have published groundbreaking findings in NPJ Breast Cancer that sheds new light on triple-negative breast cancer (TNBC), one of the most aggressive forms of breast cancer. The National Cancer Institute (NCI)-funded study, led by Dr. Lucio Miele, Director of the LSU LCMC Health Cancer …