By: Liz Highleyman From: cancerhealth.com The Food and Drug Administration (FDA) recently approved several new therapies for breast cancer, including for patients with metastatic (Stage IV) cancer and hard-to-treat triple-negative breast cancer (TNBC). Because treatment is continually evolving, it is often possible to move on to new medications if current ones stop working. Breast cancer, classified by the type of …
Turning the tables on chemotherapy resistance: LIG1 loss exposes a therapeutic vulnerability in triple-negative breast cancer
By: Molly Chiu From: bcm.ed oss of one copy of the DNA Ligase I (LIG1) gene in triple-negative breast cancers (TNBC) with TP53 mutations confers resistance to chemotherapy, but researchers at Baylor College of Medicine and collaborating institutions have identified a vulnerability in these cells and used it to their advantage. The team identified underlying molecular mechanisms of platinum resistance …
Estrogen Receptor (ER) Positive Breast Cancer
From: healthline.com Key Takeaways ER-positive breast cancer means cancer cells have estrogen receptors that promote tumor growth when bound to estrogen. It is the most common type of breast cancer. Treatment for ER-positive breast cancer often involves hormone therapy to block estrogen from activating cancer cell growth, and depending on the stage, may also include surgery and chemotherapy. The outlook …
7 Ways to Keep Your Bones Strong Through Breast Cancer Treatment
From: healthline.com Key takeaways Certain breast cancer treatments can weaken bones, so it’s important to discuss bone-strengthening medications with your doctor if you’re going through breast cancer treatment. Weight-bearing and resistance exercises are crucial for maintaining bone health during breast cancer treatment. It’s best to aim for a mix of both on most days of the week. Adequate intake of …
How Urgent Is Surgery for Breast Cancer?
From: healthline.com Key takeaways Target timelines for breast cancer surgery can vary. Generally, primary breast cancer is ideally done within 8 weeks from diagnosis. This allows for thorough testing and decision-making without affecting outlook. Research indicates that delays in surgery beyond 8 weeks may potentially lower overall survival rates. However, other factors beyond scheduling also play a role. Factors such …
New mechanism behind breast cancer metastasis uncovered
By Ingrid Söderbergh, Umea University From: medicalxpress.com Researchers at Umeå University show that the protein METTL3 helps breast cancer cells spread. By regulating the release of molecules, METTL3 makes it easier for tumors to invade surrounding tissue and form metastases. The discovery reveals a previously unknown function of METTL3 and could influence future cancer treatments. The study has been published …
What is Stage 0 Breast Cancer
From: healthline.com Key takeaways Stage 0 breast cancer, also known as ductal carcinoma in situ (DCIS), is a non-invasive condition where atypical cells are present in the milk ducts but haven’t spread beyond the duct walls, and while it’s not considered invasive, it has the potential to become so if untreated. Diagnosis of stage 0 breast cancer typically occurs during …
What is bilateral breast cancer?
From: mdanderson.org When breast cancer develops in both breasts, it’s called bilateral breast cancer. This accounts for 1.4% to 11% of all breast cancer diagnoses, according to the National Institutes of Health. Bilateral breast cancer is not as common as unilateral breast cancer (breast cancer in just one breast). As with all types of breast cancer, the chances of successful …
Deeper Responses Linked to Improved Long-Term Outcomes With T-DXd/Pertuzumab in HER2+ Breast Cancer
By: Ashling Wahner From: onclive.com Patients with HER2-positive advanced or metastatic breast cancer who achieved a complete response (CR) or deep partial response (PR) to first-line trastuzumab deruxtecan (T-DXd; Enhertu) plus pertuzumab (Perjeta) experienced improved long-term outcomes, including more durable progression-free survival (PFS) outcomes and longer treatment durations, compared with those who experienced responses that were less deep, according to …
Ask the Expert: Is It Possible to Skip Chemotherapy in Breast Cancer Treatment?
From: healthline.com Not all people with breast cancer will need chemotherapy. But doctors may recommend it for certain situations, such as before surgery to shrink a tumor and after surgery to kill any remaining cancer cells. Which initial treatments are more commonly being used in place of chemotherapy? In ER-positive breast cancer, if the Oncotype DX is in the range …