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Where Does T-DM1 Fit In First-Line Treatment for HER2-Positive Breast Cancer?

In Clinical Trials by Barbara Jacoby

By: Dave Levitan From: www.cancernetwork.com Trastuzumab emtansine (T-DM1) with or without pertuzumab yielded good overall survival in patients with HER2-positive metastatic breast cancer according to the results of a phase III trial published in Cancer. Though these were not superior to survival seen with taxane-based therapy, T-DM1 should be considered an option for first-line therapy in patients deemed unsuitable for …

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Final Results of the KRISTINE Trial in HER2-Positive Breast Cance

In Clinical Trials by Barbara Jacoby

By: Dave Levitan From: cancernetwork.com Treatment for HER2-positive breast cancer with trastuzumab emtansine (T-DM1) plus pertuzumab yielded a higher risk of event-free survival (EFS) events compared with trastuzumab, pertuzumab, and chemotherapy, according to a phase III trial. There was a similar risk of invasive disease–free survival (IDFS) events, though, suggesting that chemotherapy may be unnecessary in some patients. The standard …