Source: Scripps Research Institute From: sciencedaily.com Our immune system’s arsenal of defenses usually protects us from cancer. But sometimes, cancer cells overwhelm or evade this elaborate defense system. In the lab of biochemist and immunologist Christoph Rader, PhD, associate professor at The Scripps Research Institute in Florida, scientists have engineered a new type of anti-cancer antibody, one intended to enhance …
‘Click chemistry’ reactions may boost cancer-fighting drug potency
Source: Scripps Research Institute From: sciencedaily.com Researchers at The Scripps Research Institute (TSRI) have developed a quick and easy way to simultaneously modify dozens of drugs or molecules to improve their disease-fighting properties. Using the approach, scientists exchanged one chemical group for another in 39 cancer drugs — and discovered under lab conditions that the chemically altered versions of three …
‘Double decker’ antibody technology fights cancer
Source: Scripps Research Institute From: sciencedaily.com Scientists from the Florida campus of The Scripps Research Institute (TSRI) have created a new class of antibody-drug conjugates (ADCs), using a versatile “double decker” technology that ties antibodies and a drug together to produce highly potent pharmaceuticals for cancer therapy. The new ADC technology advances a class of pharmaceuticals that use antibodies to …
Cancer cells metastasize far earlier than suspected
By: Bradley J. Fikes From: sandiegouniontribune.com Solid tumors can metastasize far earlier than previously thought, according to a study by scientists at The Scripps Research Institute. Tumor cells nearly always get into the bloodstream at the core, not the periphery, as the conventional model states. These cells become mobile before the primary tumor starts invading nearby tissue, the study found. …