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Israeli genetic research may lead to new treatments for breast cancer

In In The News by Barbara Jacoby

Source: Xinhua From: xinhuanet.com Israeli researchers have found that the malfunction of two key genes often causes cancer, which may lead to new treatments for breast cancer, the Weizmann Institute of Science reported Thursday. The two genes, LATS1 and LATS2, are on a chain of biochemical reactions called the “hippo pathway.” Defects in this pathway in humans often lead to …

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How destroying a tumor promoter could lead to new cancer treatments

In In The News by Barbara Jacoby

By: Catharine Paddock PhD From: medicalnewstoday.com Scientists have cracked a cell mechanism that drives tumor formation in most types of cancer. This finding could lead to much-needed new therapies for cancer, including the hard-to-treat triple-negative breast cancer. The discovery concerns the molecular activity of the tumor suppressor protein p53. This protein sits inside the nucleus of the cell and protects …

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It’s not time to freak out that Crispr will cause cancer—yet

In In The News by Barbara Jacoby

By: Katherine Ellen Foley From: qz.com The biotech industry is obsessed with Crispr, the molecular gene-editing technology capable of snipping out undesired bits of genetic material and, sometimes, replacing it with preferred DNA. Theoretically, Crispr capabilities could make curing previously incurable genetic conditions like cystic fibrosis a possibility for the first time. But on Monday (June 11), two new studies published side by sidein Nature Medicine …

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Combination breast cancer therapy targets tumor cells and the blood vessels that feed them

In In The News by Barbara Jacoby

Source: University of Missouri-Columbia From: sciencedaily.com Each day, normal human cell tissues express a protein known as p53 that wages war against potential malignancies. However, between 30 and 40 percent of human breast cancers express a defective (mutant) form of p53 that helps cancer cells proliferate and grow. Now, researchers at the University of Missouri have found that combining a …

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Tumor-suppressing protein actually promotes cancer

In In The News by Barbara Jacoby

Source: Tulane University From: sciencedaily.com Tulane University researchers have discovered that the protein PHLDB3, thought to be a potential tumor suppressor, actually allows cancer cells to thrive in pancreatic, prostate, colon, breast, lung, and other common cancers. The discovery could explain how cancer is able to overcome p53 — a key tumor-suppressing protein. The findings, recently published in Nature Communications, …