View Post

Metastatic Breast Cancer Genomes Point to Distinct Features, Tumor Evolution

In Clinical Trials by Barbara Jacoby

By: Staff Reporter From: genomeweb.com A team from France, Switzerland, and the US has characterized genomic alterations that are specific to advanced, metastatic forms of breast cancer using exome sequence and clinical outcome data. As they reported online today in Nature, the researchers did whole-exome sequencing on samples from more than 600 individuals with metastatic breast cancer, identifying alterations that …

View Post

McSally’s bill would hasten health coverage for metastatic breast cancer patients

In In The News by Barbara Jacoby

By: Ripon Advance News Service From: riponadvance.com U.S. Sen. Martha McSally (R-AZ) on May 8 sponsored bipartisan legislation that would eliminate the waiting periods for disability insurance benefits and Medicare coverage for Americans having metastatic breast cancer. “Breast cancer patients don’t have time to wait months or even years to access treatment,” Sen. McSally said. “My bill would waive these …

View Post

CDK4/6 Inhibitors Firmly Established in HR+ Breast Cancer, OS Data Awaited

In Clinical Trials by Barbara Jacoby

By: Gina Columbus From: onclive.com The improvement in progression-free survival (PFS) that has been observed with CDK4/6 inhibitors in patients with metastatic hormone receptor (HR)–positive, HER2-negative breast cancer has led to changes in clinical practice. However, physicians are still awaiting further overall survival (OS) findings that will solidify the use of these agents, said Daphne B. Stewart, MD. Thus far, …

View Post

AstraZeneca, Daiichi Sankyo’s $6.9B breast cancer drug partnership bears fruit in less than two months

In Clinical Trials by Barbara Jacoby

By: Alaric DeArment   From: medcitynews.com The companies announced the partnership in March to develop trastuzumab deruxtecan, for which they plan to file approval later this year based on the successful Phase II study. The growing field of antibody-drug conjugates may soon get a new member with positive Phase II data in breast cancer. Anglo-Swedish drugmaker AstraZeneca and Japan-based Daiichi …

View Post

Susan G. Komen to hold Metastatic Breast Cancer Conference

In In The News by Barbara Jacoby

Komen Louisiana will hold its inaugural Metastatic Breast Cancer (MBC) Conference on Saturday, June 8, 2019, at Pennington Biomedical Research Center Conference Center in Baton Rouge. The event is from 8 a.m. to 5 p.m. and is free and open to those living with metastatic breast cancer and their family and friend caregivers. The daylong event provides discussions on emerging research, …

View Post

UH Cancer Center, HMSA collaborate to fight breast cancer

In Clinical Trials by Barbara Jacoby

By: Nana Ohkawa From: hawaii.edu The University of Hawaiʻi Cancer Center is working with the Hawaiʻi Medical Service Association (HMSA) to conduct a first-of-its-kind clinical trial that could lead to less anxiety for patients with metastatic breast cancer, improved quality of life for patients and their families and lower costs for the community. These changes would result from optimizing the …

View Post

New role for a driver of metastatic cancers

In In The News by Barbara Jacoby

Source: Salk Institute for Biological Studies From: prnewswire.com Salk scientists uncover the mechanism of a gene to better target cancer therapy Metastatic ovarian, prostate and breast cancers are notoriously difficult to treat and often deadly. Now, Salk Institute researchers have revealed a new role for the CDK12 protein. The findings were published in the print version of Genes & Development …

View Post

New Study Shows a Decline in the Incidence of Recurrent Metastatic Breast Cancer Over Time but no Improvement in Survival

In In The News by Barbara Jacoby

From: prnewswire.com A retrospective analysis –  reported in the journal Breast Cancer Research and Treatment, by Judith Malmgren, PhD, and co-authors – studied 8292 women with stage I-III invasive breast cancer, 964 of whom (11.6%) were later diagnosed with recurrent metastatic breast cancer (rMBC). The authors found a significant decline in rMBC over time, but no increase in survival. Survival …

View Post

What happens when breast cancer metastasizes in the lungs?

In In The News by Barbara Jacoby

By: Jamie Eske From: medicalnewstoday.com Metastatic is a term that refers to cancer that has spread outside of the original area to a different place in the body. Metastatic breast cancer in the lungs refers to cancer that originally developed inside the breast tissue but has spread to the lungs. Breast cancer is the most common form of cancer among …

View Post

Fibrosis-targeting drugs may benefit patients with late-stage, metastatic breast cancer

In In The News by Barbara Jacoby

Source: massgeneral.org From: news-medical.net A Massachusetts General Hospital (MGH) research team has found that the overgrowth of connective called fibrosis may block the effectiveness of immunotherapies against metastatic breast cancer. Their report published in PNAS also finds that plerixafor, a drug approved to mobilize blood system stem cells in the treatment of lymphoma and multiple myeloma patients, can reduce fibrosis …