Source: Albert-Ludwigs-Universität Freiburg From: news-medical.net Freiburg researchers discover a mechanism by which cancer cells escape the immune system. Triple-negative breast cancer (TNBC) is the most aggressive and deadly form of breast cancer with limited treatment options and a high probability of recurrence. Tumor growth and relapse of TNBC are driven by breast cancer stem cells, and improved therapies that can …
Two simple biomarkers could differentiate which young women with ER+ breast cancer need chemotherapy
From: news-medical.net New research from Yale Cancer Center identified that two simple biomarkers, immune cells and estrogen receptor levels, could differentiate which young women with ER+ breast cancer need chemotherapy to improve their survival, and which only need a monthly injection to suppress ovarian function. The findings were recently published in npjBreast, Nature Partner Journals. Two large clinical trials, the …
Disrupted immune cell navigation in lymph nodes of breast cancer patients
From: miragenews.com In breast cancer, tumours of different types have divergent effects on the functioning of the lymph nodes. In patients with invasive breast cancer, the blood vessels and supporting tissue of the lymph nodes change, but this does not occur in patients with a non-invasive form of breast cancer (ductal carcinoma in situ). This is shown in a new …
Immune Cells Linked to Very Early Spread of Breast Cancer
By: Marilynn Larkin From: reuters.com Normal immune cells that live near milk ducts in healthy breast tissue may play a key role in helping early breast cancer cells leave the breast for other parts of the body, researchers say. This could possibly cause cancer to metastasize, or spread, even before a tumor has developed, according to Dr. Julio Aguirre-Ghiso of …
Immune cells play key role in early breast cancer metastasis even before a tumor develops
Source: The Mount Sinai Hospital / Mount Sinai School of Medicine From: sciencedaily.com Mount Sinai researchers have discovered that normal immune cells called macrophages, which reside in healthy breast tissue surrounding milk ducts, play a major role in helping early breast cancer cells leave the breast for other parts of the body, potentially creating metastasis before a tumor has even …
Penn researchers discover how DNA damage turns immune cells against cancer
Source: pennmedicine.org From: news-medical.net Cancer is essentially a disease of the cell replication cycle. The goal of treating the disease is to permanently kill off the cells that replicate with abandon without any molecular brakes. Chemotherapy and radiation cause breaks in DNA, and eventually, death even in these out-of-control cells. Within minutes after being exposed to treatment, cancer cells call …
Implant ‘traps’ spreading cancer cells
From: bbc.com A small sponge-like implant that can mop up cancer cells as they move through the body has been developed by US researchers. So far tested in mice, it is hoped the device could act as an early warning system in patients, alerting doctors to cancer spread. The implant also seemed to stop rogue cancer cells reaching other areas …
Biotech Makes Personalized Cancer Vaccines Using Tumor Samples
By: Susan Young Rojahn From: technologyreview.com A highly personalized medical technique is allowing patients with advanced kidney cancer to live nearly three times as long as they normally do. In an experiment involving 21 patients, around half lived more than two and half years after diagnosis with kidney cancer that had begun to spread. Five patients are alive after more …
Stress: A Cause Of Breast Cancer?
By Peter Zafirides, M.D. Ohio State University researchers say the study suggests a specific gene, called ATF3, may be the crucial link between stress and cancer, including metastasis – the major cause of cancer death. Previous public health studies have shown that stress is a risk factor for cancer. Researchers already know that ATF3 is activated, or expressed, in response …
Stress: A Cause Of Breast Cancer?
By Peter Zafirides, M.D. Ohio State University researchers say the study suggests a specific gene, called ATF3, may be the crucial link between stress and cancer, including metastasis – the major cause of cancer death. Previous public health studies have shown that stress is a risk factor for cancer. Researchers already know that ATF3 is activated, or expressed, in response …