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Decoding the structure of an RNA-based CRISPR system

In In The News by Barbara Jacoby

Salk Institute researchers uncover molecular details of a new genetic engineering tool Over the past several years, CRISPR-Cas9 has moved beyond the lab bench and into the public zeitgeist. This gene-editing tool holds promise for correcting defects inside individual cells and potentially healing or preventing many human ailments. But the Cas9 system alters DNA, not RNA, and some experts believe …

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Tweaking cells’ gatekeepers could lead to new way to fight cancer

In In The News by Barbara Jacoby

Salk scientists develop method to manipulate numbers of nuclear pores If the cell nucleus is like a bank for DNA, nuclear pores are the security doors around its perimeter. Yet more security doors aren’t necessarily better: some cancer cells contain a dramatic excess of nuclear pores. Salk Institute researchers reported on September 18, 2018, in the journal Genes & Development …

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New method of pinpointing cancer mutations could lead to more targeted treatments

In In The News by Barbara Jacoby

Salk Institute researchers and collaborators develop approach to yield more complete picture of cancer Cancer cells often have mutations in their DNA that can give scientists clues about how the cancer started or which treatment may be most effective. Finding these mutations can be difficult, but a new method may offer more complete, comprehensive results. A team of researchers has …

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New Blood Test May Detect Multiple Types of Cancer at Earlier Stages

In In The News by Barbara Jacoby

From: healthline.com Screening methods for certain types of cancer, particularly breast cancer and prostate cancer, can lead to early diagnosis. However, there’s no catchall test to screen for every one of the more than 100 types of cancer that exist. Researchers at GRAIL, a Silicon Valley healthcare company, are working on a DNA test based off a simple blood draw that can …

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Lung cancer tumor growth halved with new approach

In In The News by Barbara Jacoby

By: Maria Cohut From: medicalnewstoday.com New research from Sweden has taken strides toward finding a cure for lung cancer. It focused on noncoding molecules that have been puzzling scientists for a long time. According to the National Cancer Institute (NCI), lung cancer caused around 25.9 percent of all cancer-related deaths last year and accounted for 13.2 percent of all new …

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DNA that causes cancer could one day be SNIPPED out of people’s bodies – thanks to amazing new breakthrough

In In The News by Barbara Jacoby

By: Miriam Stoppart From: mirror.co.uk There always has been good news about cancer, but often it’s ignored or not shouted about. Well, I’m going to be shouting. One of the fascinating innovations I’ve been following for some time is CRISPR technology that can act as tiny molecular scissors and cut out damaged and sometimes cancer-promoting bits of DNA . It’s …

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‘Exciting’ blood test spots cancer a year early

In In The News by Barbara Jacoby

By: James Gallagher From: bbc.com Doctors have spotted cancer coming back up to a year before normal scans in an “exciting” discovery. The UK team was able to scour the blood for signs of cancer while it was just a tiny cluster of cells invisible to X-ray or CT scans. It should allow doctors to hit the tumour earlier and …

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Researchers at the Gene Editing Institute at Christiana Care Health System develop new system to perform precise ‘surgery’ on the human genome

In In The News by Barbara Jacoby

Molecular biologists at Christiana Care Health System’s Gene Editing Institute have developed a new system that allows them to not only repair damaged DNA within human cells, but also to determine when the DNA repair machinery has introduced unwanted genetic changes alongside, or instead of, the desired repair. A team of researchers led by Eric Kmiec, Ph.D., director of the …

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Johns Hopkins researchers develop new, highly accurate urine test to predict risk for cervical cancer

In In The News by Barbara Jacoby

Source: John Hopkins Medicine From: news-medical.net Johns Hopkins Medicine specialists report they have developed a urine test for the likely emergence of cervical cancer that is highly accurate compared to other tests based on genetic markers derived directly from cervical tissue. The new urine test, they say, is different because it analyzes not only multiple sources of human cellular DNA …

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Quadruple helix form of DNA may aid in development of targeted cancer therapies

In In The News by Barbara Jacoby

Source: University of Cambridge From: sciencedaily.com Scientists have identified where a four-stranded version of DNA exists within the genome of human cells, and suggest that it may hold a key to developing new, targeted therapies for cancer. In work funded by Cancer Research UK and EMBO, the researchers, from the University of Cambridge, found that these quadruple helix structures occur …