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Study examines metabolic reprogramming of breast cancer tumors during neoadjuvant chemotherapy

In In The News by Barbara Jacoby

By: Karolinska Institutet From:medicalxpress.com In a study published in Nature Communications, scientists have made significant strides in understanding the complex interplay between the immune system and cancer metabolism in breast cancer treatment. The research offers new insights into how the immune state and cancer metabolism evolve during neoadjuvant chemotherapy (NAC). The study utilized proteomics, genomics, transcriptomics and histopathology to analyze tumor tissue …

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Chemotherapy linked to physical decline in older women with high-risk breast cancer

In In The News by Barbara Jacoby

Source: University of California – Los Angeles Health Sciences From: news-medical.net A UCLA-led study suggests women who are 65 years old or older with high-risk breast cancer and are treated with chemotherapy are more likely to develop a substantial decline in physical function. The study, published in a special issue of the Journal of Cancer Survivorship, found over 30% of older …

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More chemo response details needed in breast MRI reporting

In In The News by Barbara Jacoby

By: Amerigo Allegretto From: auntminnie.com Several neoadjuvant chemotherapy response characteristics are often left out of breast MRI reports, suggest findings presented May 7 at the American Roentgen Ray Society (ARRS) annual meeting. In a talk delivered at the conference, Sheida Ebrahimi, MD, from the University of California, San Diego presented her team’s study, which showed that little to no reports …

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Ending Oncology’s Toxic Relationship With High Chemotherapy Doses

In In The News by Barbara Jacoby

By: Mikkael A. Sekeres, MD, MS From: medpagetoday.com Many years ago, my patient, a woman in her fifties with chronic myeloid leukemia (CML), got her routine, yearly lab work returned showing a white blood cell count that was 10 times higher than normal. In my practice, which focuses exclusively on treating patients with leukemias and related myeloid cancers, seeing someone …

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Breast cancer patients can safely avoid extensive removal of lymph nodes if they respond well to systemic treatment

In In The News by Barbara Jacoby

By: European Organisation for Research and Treatment of Cancer From: medicalxpress.com Patients with breast cancer that has started to spread to the lymph nodes in the armpit can safely avoid extensive removal of the lymph nodes if their treatment is tailored to their response to cancer-killing therapies such as chemotherapy before surgery. In a presentation to the 14th European Breast …

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Pembrolizumab May Improve Breast Cancer Outcomes Regardless of Age or Menopausal Status

In In The News by Barbara Jacoby

From: ascopost.com The addition of the immunotherapy drug pembrolizumab to chemotherapy prior to and following surgery may lead to improved outcomes in patients with breast cancer regardless of their age or menopausal status, according to new findings presented by Cardoso et al at the 2024 European Breast Cancer Conference (EBCC) (Abstract 4). The research adds to data on the effect …

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Gut Microbiome Affects GI Burden Symptom of Chemotherapy for Breast Cancer

In In The News by Barbara Jacoby

By: Megan Garlapow, PhD From: oncologynurseadvisor.com Results from a comprehensive gastrointestinal (GI) assessment and analysis of the gut microbiome in patients with breast cancer undergoing chemotherapy indicated potential microbiome effects of the burden of GI symptoms. In this study, bacteria of the gut microbiome were correlated with GI inflammation and mucus degradation in 22 patients with breast cancer undergoing chemotherapy, …

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New study challenges long-held belief about how chemotherapy works

In In The News by Barbara Jacoby

Source: University of Wisconsin-Madison From: news-medical.net A new study from the University of Wisconsin–Madison suggests that chemotherapy may not be reaching its full potential, in part because researchers and doctors have long misunderstood how some of the most common cancer drugs actually ward off tumors. For decades, researchers have believed that a class of drugs called microtubule poisons treat cancerous tumors …

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Fasting During Breast Cancer Chemo Improves Quality of Life

In In The News by Barbara Jacoby

By: Megan Brooks From: medscape.com Short-term fasting during chemotherapy enhances health-related quality of life in patients with early breast cancer, with no untoward effects, according to late-breaking research presented on day 1 of the European Society for Medical Oncology (ESMO) Congress 2023. “Strikingly,” fasting also appeared to prevent fatigue, something patients with breast cancer struggle with, Daniela A. Koppold, MD, …

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Neoadjuvant Pembrolizumab Plus Chemotherapy Boosts pCR in ER+/HER2- Breast Cancer

In In The News by Barbara Jacoby

By: Ashling Wahner From: onclive.com Neoadjuvant pembrolizumab (Keytruda) plus chemotherapy followed by adjuvant pembrolizumab plus endocrine therapy generated a statistically significant increase in pathologic complete response (pCR) vs neoadjuvant placebo plus chemotherapy followed by adjuvant pembrolizumab and endocrine therapy in patients with high-risk, early-stage, estrogen receptor (ER)–positive, HER2-negative breast cancer, according to data from the phase 3 KEYNOTE-756 trial (NCT03725059) …