By: Molly Chiu From: bcm.edu Loss of one copy of the DNA Ligase I (LIG1) gene in triple-negative breast cancers (TNBC) with TP53 mutations confers resistance to chemotherapy, but researchers at Baylor College of Medicine and collaborating institutions have identified a vulnerability in these cells and used it to their advantage. The team identified underlying molecular mechanisms of platinum resistance …
Roswell Park Team Identifies New Cause of Chemotherapy Resistance in Triple-Negative Breast Cancer
Source: Roswell Park Comprehensive Cancer Center From: onclive.com Key Takeaways TNBC is aggressive, often resistant to chemotherapy, and has a poor prognosis, especially with high IMPDH2 expression. IMPDH2 aids in doxorubicin resistance, but its inhibition by drugs like ribavirin and mycophenolic acid can reduce tumor growth. IMPDH2-inhibitor drugs, already FDA-approved for other conditions, show promise in targeting chemo-resistant TNBC. The …
Researchers mark milestone in progress toward investigational new drug for triple-negative breast cancer
By: Leslie Cantu, Medical University of South Carolina From: medicalxpress.com A new compound developed by researchers at MUSC Hollings Cancer Center shows promise in overcoming chemotherapy resistance in triple-negative breast cancer—and could potentially be applied to fibrotic conditions like liver fibrosis or pulmonary fibrosis. At the center of this work is preventing the protein lysyl oxidase, or LOX, from going …
Biological Markers Uncovered in Triple-Negative Breast Cancer
From: genengnews.com Neoadjuvant chemotherapy (NAC) is the standard of care for many triple-negative breast cancer (TNBC patients), who lack estrogen and progesterone receptors as well as the HER2 receptor. Although NAC is effective in some TNBC patients, approximately half will develop chemotherapy resistance. Researchers are working to develop and improve approaches that overcome resistance to chemotherapy. Now, researchers at Baylor …
Researchers identify markers of chemotherapy resistance and outcome in triple negative breast cancer
By: Molly Chiu, Baylor College of Medicine From: medicalxpress.com Researchers at Baylor College of Medicine and the Broad Institute of MIT and Harvard and clinicians at Washington University in St. Louis have identified biological markers in triple negative breast cancer (TNBC) that are associated with resistance to chemotherapy treatment. The study is published in the journal Cancer Discovery and was …
Biomarker could help guide cancer therapy, avoid drug resistance
By: Anne Trafton From: mit.edu MIT biologists have identified a new biomarker that can reveal whether patients with a particularly aggressive type of breast cancer will be helped by paclitaxel (commercially known as Taxol), one of the drugs most commonly used to treat this cancer. The findings could offer doctors a new way to choose drugs for this type of …
Study uncovers mechanism that causes chemo resistance of pancreatic cancer cells
Source: University of Liverpool From: www.news-medical.net A pioneering University of Liverpool research team have published a study that identifies the mechanism in the human body that causes resistance of pancreatic cancer cells to chemotherapy. Pancreatic cancer is one of the leading causes of cancer death and current therapies are not very effective. Thus, a better understanding of the molecular mechanisms …
Uncovering a new principle in chemotherapy resistance in breast cancer
From: nih.gov Reported by: Redington Life Sciences News A laboratory study has revealed an entirely unexpected process for acquiring drug resistance that bypasses the need to re-establish DNA damage repair in breast cancers that have mutant BRCA1 or BRCA2 genes. The findings, reported by Andre Nussenzweig, Ph.D., and Shyam Sharan, Ph.D., at the National Cancer Institute (NCI), part of the …