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Using cell metabolism to battle cancer

In In The News by Barbara Jacoby

By: Tim Newman From: medicalnewstoday.com By focusing on how cancer stem cells metabolize, researchers may have uncovered a new way to defeat them: by attacking their energy supply. Drug resistance is a sizable problem for cancer treatment. Medications that might initially work will soon become ineffective. Scientists from the University of Michigan Rogel Cancer Center in Ann Arbor are focusing on how cancer stem …

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Aggressive cancer stem cells can now be isolated successfully in a scientific breakthrough

In In The News by Barbara Jacoby

By: Dr Ananya Mandal, MD From: news-medical.net University of Texas at Dallas researchers have managed to formulate a new technique by which they can isolate aggressive cells which can be the main cause behind metastasized cancers or cancers that have spread to other major organs from their primary site of occurrence. This breakthrough may lead to isolation of these cells …

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Vitamin deficiency ‘puts cancer cells into hibernation’

In In The News by Barbara Jacoby

Source: University of Salford From: sciencedaily.com A new potential therapeutic agent, diphenyleneiodonium chloride (DPI), effectively switches off cancer stem cells, preventing their proliferation, researchers report. “It’s extraordinary; the cells just sit there as if in a state of suspended animation,” explains Professor Michael Lisanti, Chair of Translational Medicine and lead investigator. The discovery is significant because the drug halts the …

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How some breast cancer cells return after chemo

In In The News by Barbara Jacoby

By: Shawna Williams From: futurity.org Researchers have identified a biochemical chain of events that allows some breast cancer cells to survive chemotherapy and restart tumor growth. The recurrence of cancer stem cells is tied to the drug resistance that develops in many breast tumors. Because of that resistance, the benefits of chemo are short-lived for many patients. Cancer recurrence after …

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Scientists provide proof of concept for potential new class of cancer drugs

In In The News by Barbara Jacoby

Source: University of Miami Miller School of Medicine From: sciencedaily.com A recent study led by scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, in collaboration with the Univerity of Maryland School of Pharmacy and StemSynergy Therapeutics, Inc., has identified a small-molecule inhibitor of the Notch pathway, paving the way for a potential new …

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Discovery of an Embryonic Switch for Cancer Stem Cell Generation

In In The News by Barbara Jacoby

From: UCSD Health Sciences News An international team of scientists, headed by researchers at UC San Diego School of Medicine and UC San Diego Moores Cancer Center, report that decreases in a specific group of proteins trigger changes in the cancer microenvironment that accelerate growth and development of therapy-resistant cancer stem cells (CSCs). The discovery suggests the basis for a …

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Epigenetic Driver of Glioblastoma Provides New Therapeutic Target

In In The News by Barbara Jacoby

From: UCSD Health Sciences Communications Enzyme turns off genes required for maintaining cancer stem cell properties Cancer’s ability to grow unchecked is often attributed to cancer stem cells, a small fraction of cancer cells that have the capacity to grow and multiply indefinitely. How cancer stem cells retain this property while the bulk of a tumor’s cells do not remains …