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CRUK tests drug combo for advanced pancreatic cancer

In Clinical Trials by Barbara Jacoby

From: pharmaphorum.com Cancer Research UK has announced it will study Plexxikon’s dual kinase inhibitor PLX7486 in combination with gemcitabine in advanced pancreatic cancer as part of its Combinations Alliance. The novel combination of drugs targets the process of nerve invasion, observed in over 80% of pancreatic ductal adenocarcinoma (PDAC) and is associated with tumour spread and severe pain. The PAGoDA …

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New dual-action cancer-killing virus

In Clinical Trials by Barbara Jacoby

From: eurekalert.org Scientists have equipped a virus that kills carcinoma cells with a protein so it can also target and kill adjacent cells that are tricked into shielding the cancer from the immune system. It is the first time that cancer-associated fibroblasts within solid tumours – healthy cells that are tricked into protecting the cancer from the immune system and …

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‘Exciting’ blood test spots cancer a year early

In In The News by Barbara Jacoby

By: James Gallagher From: bbc.com Doctors have spotted cancer coming back up to a year before normal scans in an “exciting” discovery. The UK team was able to scour the blood for signs of cancer while it was just a tiny cluster of cells invisible to X-ray or CT scans. It should allow doctors to hit the tumour earlier and …

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MIT team using VR in fight vs. cancer

In In The News by Barbara Jacoby

By: Lindsay Kalter Source: Cancer Research UK From: bostonherald.com Science fiction writers have long toyed with the concept of venturing through the human body to fight ailments from within. Now local researchers are working to make that a reality. New efforts are underway to develop technologies that will allow doctors to step inside tumors using virtual reality, giving them a …

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The biology of cancer cell shape

In In The News by Barbara Jacoby

By: Emma Smith, Science Communications team at Cancer Research UK Source: Cancer Research UK – Science Blog From: onmedica.com In a study published today in the journal Genome Research, researchers led by Dr Chris Bakal from The Institute of Cancer Research, London and funded by Cancer Research UK, reveal some key information about this strong link between cancer cell shape and patients’ outlook. This …

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Gut bacteria ‘may help drugs fight cancer’

In In The News by Barbara Jacoby

By: James Gallagher From: bbc.com Bacteria living deep inside the digestive system seem to alter how cancer drugs work, a study suggests. Immunotherapies – which harness the body’s own defences to fight tumours – can clear even terminal cancer in a small proportion of patients. However, a small study by the University of Texas found those harbouring a more diverse …

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‘Junk’ DNA plays role in preventing breast cancer University of Bath – EurekAlert

In In The News by Barbara Jacoby

University of Bath From: eurekalert.org Supposed “junk” DNA, found in between genes, plays a role in suppressing cancer, according to new research by Universities of Bath and Cambridge. The human genome contains around three metres of DNA, of which only about two per cent contains genes that code for proteins. Since the sequencing of the complete human genome in 2000, …

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Mapping cancer’s ‘social networks’ opens new approaches to treatment

In In The News by Barbara Jacoby

From: cancerresearchuk.org Cancer Research UK-funded scientists have designed a computer model that applies techniques used to analyse social networks to identify new ways of treating cancer, according to research published in PLOS Computational Biology (link is external). The model analyses the unique behaviours of cancer-causing proteins – spotting what makes them different from normal proteins, and mapping out molecular targets …

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Aspirin trial to examine if it can stop cancer returning

In In The News by Barbara Jacoby

By: Smitha Mundasad From: bbc.com The world’s largest clinical trial to examine whether aspirin can prevent cancers returning has begun in the UK. About 11,000 people who have had early bowel, breast, prostate, stomach and oesophageal cancer will be involved. Uncertainty about the drug’s possible anti-cancer qualities has led to fierce medical debate in recent years. If it is proven …

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Research finds link between oestrogen levels and male breast cancer

In In The News by Barbara Jacoby

From: news-medical.net Men with naturally high levels of the female hormone oestrogen may have a greater risk of developing breast cancer, according to research by an international collaboration including Cancer Research UK published today in the Journal of Clinical Oncology. This is the first time a link between oestrogen levels in the blood and male breast cancer has been identified, …