From: insideprecisionmedicine.com Danish researchers warn that metabolic screening should be a priority among breast cancer survivors after finding that those with metabolic syndrome are at increased risk for breast cancer recurrence and death. “Our findings suggest that metabolic health may play a role in shaping breast cancer outcomes,” said the study’s first author Sixten Harborg, MD, from the department of …
Study Links PAK5 to Poor Outcomes and Drug Resistance in HER2-Positive Breast Cancer
By: Alexandra Gerlach, Associate Editor From: pharmacytimes.com Key Takeaways PAK5 is linked to resistance in HER2-positive breast cancer, correlating with advanced cancer stages and poor outcomes. High PAK5 levels stabilize MALAT1, preventing N-HER2 breakdown and enhancing resistance through a feedback loop. Targeting PAK5 may improve treatment efficacy for patients with limited options after standard therapies fail. Researchers have identified p21-activated …
Dormancy-Driving Transcription Factors in Breast Cancer: A Key to Understanding Tumor Relapse
From: insideprecisionmedicine.com` New research sheds light on the molecular mechanisms that allow breast cancer cells to survive treatment and reawaken later, often in a more aggressive and chemoresistant form. Published in Science Signaling, the study identifies a key set of transcription factors—OVOL1 and OVOL2—that promote dormancy in aggressive breast cancer cells. These factors induce a shift in cell identity and …
Why Did I Get Breast Cancer?
View PostMany People With Cancer Wait Too Long to Start Palliative Care, Study Finds
By: Bec Roldan, PhD From: breastcancer.org For more than 15 years, healthcare workers in the U.S. have been calling attention to the importance of taking early steps to improve the quality of life in people diagnosed with advanced cancer. Despite these efforts, a recent study found that many people over 65 with advanced cancer aren’t receiving supportive care in the …
Modernizing Breast Cancer Surgery Through Ultrasound Technology
From: physiciansweekly.com Intraoperative ultrasound-guided breast-conserving surgery offers the distinct advantage of real-time visualization of tumor boundaries and resection margins, enabling more precise excision compared to traditional techniques guided by palpation or preoperative wire localization. This prospective observational cohort study, conducted at the Veneto Institute of Oncology between January 2021 and October 2022, aimed to evaluate and compare the surgical, oncologic, …
Novel Adjuvant Strategies Reshape HER2+ Breast Cancer Treatment
By: Jax DiEugenio From: onclive.com Following the publication of the KATHERINE trial (NCT01772472), a number of novel clinical trials have emerged with the use of antibody-drug conjugates (ADCs), checkpoint inhibitors, and TKIs aimed at further improving outcomes for patients with high-risk, early-stage HER2-positive breast cancer, according to Paolo Tarantino, MD. In the second part of an interview with OncLive®, Tarantino …
Researchers link 9 blood proteins to breast cancer and suggest 3 drugs for repurposing
By: Hugo Francisco de Souza From: news-medical.net In a recent study in the journal Communication Biology, researchers employed a novel combined Mendelian randomization (MR) analysis to identify 62 plasma proteins (including 9 with robust support, 13 with medium support, and 40 with limited support) associated with breast cancer and its Luminal A or B subtypes. Unlike previous approaches using only …
BCRF Investigator Discovers New Subgroups of Breast Cancer
By: Priya Malhotra, PhD From: bcrf.org Findings show structural variations in tumor cell DNA could indicate risk of recurrence or reveal tumor vulnerabilities as targets for new treatments Breast cancers are generally classified based on hormone receptor status (the presence of estrogen and progesterone receptors) and HER2 status (levels of the HER2 protein). This information can indicate how aggressive the …
Alert-based patient-reported outcome monitoring improves breast cancer symptom control
By: Mark Leiser From healio.com Key takeaways: Patients assigned the intervention had less fatigue and improved quality of life. They also exhibited a 29% reduced risk for death. Use of alerts triggered by patient-reported outcome monitoring improved symptom control for patients with advanced breast cancer, according to results of the randomized PRO B trial. The approach conferred a clinically meaningful …