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Mayo Breast Cancer Vaccine Could Be Available In Less Than A Decade

In Clinical Trials by Barbara Jacoby

By: Robin Seaton Jefferson From: forbes.com Researchers at Mayo Clinic in Jacksonville, Florida say a vaccine they have developed could be available within eight years that may not only stop the recurrence of breast and ovarian cancers, but prevent them from developing in the first place. “It is reasonable to say that we could have a vaccine within eight years …

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Seattle Genetics Announces Initiation of Phase 3 Clinical Trial of Tucatinib in Combination with Ado-trastuzumab Emtansine (T-DM1, Kadcyla®) for Patients with Advanced or Metastatic HER2-Positive Breast Cancer

In Clinical Trials by Barbara Jacoby

From: businesswire.com Seattle Genetics, Inc. (Nasdaq:SGEN) today announced dosing of the first patient in HER2CLIMB-02, a randomized phase 3 clinical trial evaluating investigational agent tucatinib versus placebo, in combination with standard-of-care ado-trastuzumab emtansine (T-DM1, Kadcyla®), for patients with locally advanced or metastatic HER2-positive (HER2+) breast cancer. This trial is intended to support registration in the U.S. Tucatinib is an oral, …

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Foreign-born women lagging behind US peers in breast cancer screening rates

In In The News by Barbara Jacoby

By: Marty Stempniak From: radiologybusiness.com Breast is the leading cancer killer for Hispanic women in the U.S., and it ranks second among white, black and Asian populations. Incidence of the disease and receipt of crucial mammography screening are often impacted by whether a woman was born in a foreign country, which can snowball into disparities in treatment outcomes. There’s been …

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Metastatic Breast Cancer: What You Should Know

In In The News by Barbara Jacoby

By: Rene Wisely From: uofmhealth.org What does it mean to have metastatic, or stage 4, breast cancer? A Rogel Cancer Center oncologist explains the diagnosis and how it’s treated. After hearing a diagnosis of metastatic breast cancer, a rush of questions emerges. But often, it’s not until long after leaving the doctor’s office. Metastatic means the cancer has spread beyond …

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Patient Selection Key When De-Escalating Radiation in Breast Cancer

In In The News by Barbara Jacoby

By: Danielle Ternyila From: onclive.com Over the past several years, several clinical trials have evaluated the role of radiation in the treatment of patients with breast cancer and whether doses can be reduced. Although de-escalation is possible, patient selection is key, according to Jonathan B. Strauss, MD, MBA. “Selecting the right patients for de-escalation is key. Right now, we are …

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TAILORx High-Risk Group Analysis Adds to Oncotype DX Chemo-Prediction Data

In Clinical Trials by Barbara Jacoby

By: Staff Reporter From: genomeweb.com In secondary analysis of data from the TAILORx trial, researchers have added new confirming evidence that patients with high risk scores from Genomic Health’s Oncotype DX appear to benefit significantly from added chemotherapy. Investigators led by the trial’s PI Joseph Sparano shared their findings in JAMA Oncology today and also presented the analysis at the …

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Use of Neoadjuvant Endocrine Therapy Showcases Testing Capabilities in Breast Cancer

In In The News by Barbara Jacoby

By: Darcy Lewis From: onclive.com In breast cancer, neoadjuvant endocrine therapy shows promise in a variety of areas, including as an excellent testing platform, Ingrid A. Mayer, MD, MSCI, said in a presentation during the 2019 Lynn Sage Breast Cancer Symposium.1 Neoadjuvant endocrine therapy allows clinicians to determine resistance mechanisms to endocrine therapy with or without targeted agents. It also …

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CytoDyn Treats First Patient in Phase 1b/2 Clinical Trial with Leronlimab (PRO 140) for Patients with Treatment-Naïve, Metastatic Triple-Negative Breast Cancer

In Clinical Trials by Barbara Jacoby

From: globenewswire.com CytoDyn Inc. (OTC.QB: CYDY), (“CytoDyn” or the “Company”), a late stage biotechnology company developing leronlimab (PRO 140), a CCR5 antagonist with the potential for multiple therapeutic indications announced today the injection of the first patient in a Phase 1b/2 clinical protocol with treatment-naïve metastatic triple-negative breast cancer (mTNBC). The treatment of the first patient in mTNBC with leronlimab …

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Data Presented at ESMO Provides Rationale for Clinical Trial of Onvansertib in Subset of Patients with Highly-Aggressive Triple Negative Breast Cancer

In Clinical Trials by Barbara Jacoby

From: prnewswire.com – Significant tumor regression observed with onvansertib in combination with standard-of-care paclitaxel in models of p53-mutated TNBC – Onvansertib preclinical data provides rationale for clinical trial targeting the 80% of TNBC that harbors the p53 mutation – Combination has potential to address critical medical need to provide targeted treatment option to overcome resistance to paclitaxel as single agent …