By: William A. Haseltine From: forbes.com There is new hope on the horizon for many women with breast cancer. New drugs have been discovered that could treat 10 to 20 percent of women with breast cancer, especially those who have an inherited predisposition to the disease due to defective BRCA1 and BRCA2 genes. For some time we knew that either …
Study Suggests 86-SNV Be Incorporated in Breast Cancer Risk Predication Models
By: Hannah Slater From: cancernetwork.com Researchers specifically suggested that the 86-SNV score could be incorporated into breast cancer risk prediction models for patients carrying a pathogenic variant in BRCA1, BRCA2, and CHEK2. Stratification of breast cancer risk by an 86-single nucleotide variation (SNV; formerly single-nucleotide polymorphisms) polygenic risk score (PRS) in pathogenic variant carriers of moderate-risk breast cancer genes was …
Hereditary Cancer Risk Variants Found in Significant Subset of Metastatic Breast Cancer Patients
By: Staff Reporter From: genomeweb.com Investigators from Johns Hopkins University School of Medicine and the Vanderbilt Ingram Cancer Center have demonstrated that there is a potential benefit to doing widespread hereditary cancer risk testing in individuals with metastatic breast cancer. “[O]ur results provide evidence to support genetic testing for inherited cancer predisposition among all patients with metastatic breast cancer, because …
Breast Cancer Drug Promising in Phase 3 Trial
By: Steven Reinberg From: consumer.healthday.com For women with advanced breast cancer who carry the BRCA1 and BRCA2 gene mutations, an experimental drug could improve survival, a new study suggests. The BRCA mutations are linked with a greater risk for aggressive breast and ovarian cancer. The drug, talazoparib, works by blocking an enzyme called poly ADP ribose polymerase (PARP), thus preventing …
When it comes to breast cancer treatment, is a double mastectomy a good idea?
By: Elli Jacobs From: smh.com.au In 2013, Renee Gani, then 36, received the news every woman dreads. “Being large-busted, I always had a habit of checking myself,” she says. “I found a lump in my right breast and waited for a week hoping it would disappear.” But a biopsy confirmed it was indeed breast cancer. “My immediate thought was to …
Genetic tests can help with predicting some cancers, treating others
By: Stacey Federoff From: timesonline.com Rosemary Wargula of Hopewell Township has folders’ worth of papers with information about her last 12 years battling cancer, beginning in 2004. A nurse for more than 40 years before she retired, Wargula, 72, put on red reading glasses held around her neck with a string of beads to read from a small notebook, where …
Uncovering a new principle in chemotherapy resistance in breast cancer
From: nih.gov Reported by: Redington Life Sciences News A laboratory study has revealed an entirely unexpected process for acquiring drug resistance that bypasses the need to re-establish DNA damage repair in breast cancers that have mutant BRCA1 or BRCA2 genes. The findings, reported by Andre Nussenzweig, Ph.D., and Shyam Sharan, Ph.D., at the National Cancer Institute (NCI), part of the …
Uncovering a new principle in chemotherapy resistance in breast cancer
Source: National Institutes of Health From: nih.gov A laboratory study has revealed an entirely unexpected process for acquiring drug resistance that bypasses the need to re-establish DNA damage repair in breast cancers that have mutant BRCA1 or BRCA2 genes. The findings, reported by Andre Nussenzweig, Ph.D., and Shyam Sharan, Ph.D., at the National Cancer Institute (NCI), part of the National …
Beyond the Pink Moon
View PostCould ‘breast cancer genes’ play role in prostate cancer, too?
By: Dennis Thompson, Health Day News From: upi.com A man’s risk of aggressive and lethal prostate cancer may be heavily influenced by gene mutations previously linked to breast and ovarian cancer in women, a trio of new studies suggests. And, at least one expert says these findings may indicate that men with a history of breast cancer in their family …
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