View Post

Just Launched: New Website for People Living With MBC Brain Metastasis

In In The News by Barbara Jacoby

From: curetoday.com The MBC Alliance is honored to have served as a catalyst and partner in the creation and launch of a new website. The MBC Alliance is honored to have served as a catalyst and partner in the creation and launch of a new website, MBCBrainMets.org. As the first one-stop resource hub for breast cancer patients living with brain …

View Post

HER2CLIMB: Tucatinib Boosts OS in Breast Cancer Patients With Brain Mets

In In The News by Barbara Jacoby

By: Greg Laub From: medpagetoday.com — Updated results show 9-month survival benefit in those with active or untreated brain metastases At the virtual San Antonio Breast Cancer Symposium, researchers presented new data from an exploratory analyses from the pivotal HER2CLIMB trial. After an additional 15.6 months of follow-up, the overall survival (OS) benefit when tucatinib (Tukysa) was added to trastuzumab …

View Post

Celcuity Announces Clinical Trial Collaboration with University of Rochester Wilmot Cancer Center and Puma to Study Patients with Breast Cancer Brain Metastases

In Clinical Studies News by Barbara Jacoby

From: businesswire.com Study will evaluate the efficacy and safety of NERLYNX® plus XELODA® in patients selected by the CELsignia® Test who have metastatic HER2-negative breast cancer with brain metastases The unique tumor insights CELsignia generates enable identification of new potential applications for targeted therapies and development of potential first-in-class drugs Celcuity Inc. (Nasdaq: CELC), a clinical-stage biotechnology company pursuing an …

View Post

Clinical trial demonstrates focused ultrasound can deliver antibody therapy to breast cancer metastases in the brain

In Clinical Studies News by Barbara Jacoby

By: Focused Ultrasound Foundation From: medicalxpress.com In a first-in-world clinical trial, researchers at Sunnybrook Health Sciences Centre in Toronto, Canada, have demonstrated that magnetic resonance (MR)-guided focused ultrasound can be used to safely deliver antibody therapy to breast cancer that has metastasized to the brain. In this Phase I clinical trial for Her2-positive breast cancer patients, the Sunnybrook team captured …

View Post

Potential new treatment strategy for breast cancer cells that have spread to the brain

In Clinical Studies News by Barbara Jacoby

Source: Massachusetts General Hospital From: eurekalert.org New research reveals that when breast cancer cells spread to the brain, they must boost production of fatty acids, the building blocks of fat, in order to survive there. The work, which is published in Nature Cancer and was led by investigators at Massachusetts General Hospital (MGH) and the Koch Institute of the Massachusetts …

View Post

Research Moves Full Steam Ahead With Brain Metastases, Leptomeningeal Disease in Breast Cancer

In Clinical Studies News by Barbara Jacoby

By: Gina Mauro From: onclive.com Targeted agents and chemotherapy regimens are at the crux of systemic research efforts focused on improving outcomes for patients with breast cancer who have brain metastases and/or leptomeningeal disease. Targeted agents and chemotherapy regimens are at the crux of systemic research efforts focused on improving outcomes for patients with breast cancer who have brain metastases …

View Post

Researchers discover key driver of the spread of cancer to the brain

In Clinical Studies News by Barbara Jacoby

Source: Virginia Commonwealth University From: eurekalert.org Approximately 200,000 cancer patients are diagnosed with brain metastases each year, yet few treatment options exist because the mechanisms that allow cancer to spread to the brain remain unclear. However, a study recently published in the journal Cancer Cell by VCU Massey Cancer Center scientist Suyun Huang, M.D., Ph.D., offers hope for the development …

View Post

Gene could slow down tumor repair in breast cancer brain metastasis

In Clinical Studies News by Barbara Jacoby

By: Jennifer Chen, Yale University From: medicalxpress.com Treating tumors presents a tricky conundrum: a higher dose of radiation is more effective for treatment, but the higher the dose, the more danger it poses to healthy cells. Researchers at Yale have made significant inroads into solving this problem in a paper titled, “LRRC31 inhibits DNA repair and sensitizes breast cancer brain …

View Post

Scientists explore combination therapies for breast cancer brain metastases

In Clinical Studies News by Barbara Jacoby

By: Northwestern University From: medicalxpress.com Breast cancer is the most frequent neoplasm among women, impacting 2.1 million women per year. It also has a high risk for intracranial spread. Researchers estimate that up to 30% of all patients with cancer will eventually develop brain metastases, which heralds a poor prognosis and a low quality of life. In recent years, combining …

View Post

New therapy targets breast cancer metastases in brain

In Clinical Studies News by Barbara Jacoby

By: Northwestern University From: medicalxpress.com When breast cancer spreads to the brain, the prognosis is grim. Patients only have about six months to live. Women with HER2-positive breast cancer tend to develop brain metastases in up to 55% of cases. Chemotherapy drugs targeting breast cancer cells in the brain aren’t effective, because they can’t cross the blood-brain-barrier. But a new …