From: targetedonc.com In the first article of a 2-part series, Aditya Bardia, MD, MPH, leads a discussion on what factors influence sequencing treatment for patients with estrogen receptor positive advanced breast cancer. CASE SUMMARY A 62-year-old woman presented with a 6 cm right breast mass, which has been slowly growing for 1 year with palpable axillary nodes. Her liver function test …
PET/CT-FDG vs Conventional Staging in Locally Advanced Breast Cancer
By: Matthew Stenger From: ascopost.com In a Canadian study reported in the Journal of Clinical Oncology, Dayes et al found that positron-emission tomography/computed tomography–fluorodeoxyglucose (PET/CT-FDG) improved the detection of distant metastasis vs conventional staging in patients with locally advanced breast cancer. It also reduced the use of curative-intent combined-modality therapy. Study Details In the open-label trial, 369 patients with invasive …
Capivasertib Demonstrates Potential PFS Advantage in HR+ Advanced Breast Cancer
By: Kristi Rosa From: oncnursingnews.com Patients with hormone receptor–positive advanced breast cancer achieved superior progression-free survival (PFS) with capivasertib plus fulvestrant (Faslodex) than with fulvestrant alone. PFS benefit was also reported those who previously received a CDK4/6 inhibitor, chemotherapy in the advanced setting, or had baseline liver metastases.1 Data from an exploratory analysis of PFS in key subgroups from the …
MONALEESA-2 Subgroup Analysis Highlights Survival Benefit With Ribociclib/Letrozole in HR+ Breast Cancer
By: Courtney Flaherty From: onclive.com The frontline combination of ribociclib (Kisqali) and letrozole significantly prolonged overall survival (OS) over letrozole alone in a subset of patients with hormone receptor–positive, HER2-negative advanced breast cancer who had de novo metastatic disease or late recurrence from neoadjuvant therapy, according to data from an exploratory analysis of the phase 3 MONALEESA-2 trial (NCT01958021).1 Findings …
New interactive tool helps to calculate risk of developing advanced breast cancer
Source: University of California, San Francisco (UCSF) From: news-medical.net Breast cancer is now the leading cause of global cancer incidence among women but determining who will develop breast cancer is still a challenge for the medical community. A new tool, developed by researchers from UCSF and several other medical institutions, helps to calculate risk for those who may develop advanced …
HUTCHMED Initiates a Phase Ib/II Trial of Fruquintinib in Combination with Tislelizumab in Advanced Triple Negative Breast Cancer or Advanced Endometrial Cancer
Source: HUTCHMED (China) Limited From: globenewswire.com HUTCHMED (China) Limited (“HUTCHMED”) (Nasdaq/AIM: HCM; HKEX:13) has initiated a Phase Ib/II study of fruquintinib in combination with BeiGene’s tislelizumab in patients with advanced triple negative breast cancer (“TNBC”) or advanced endometrial cancer (“EC”) in the U.S. The first patient was dosed on August 24, 2021. This trial is to explore the potential for …
Zydus Cadila gets USFDA nod for breast cancer treatment drug
From: moneycontrol.com Fulvestrant injection is used alone or in combination with other drugs to treat a certain type of hormone receptor positive, advanced breast cancer (breast cancer that depends on hormones such as estrogen to grow) or breast cancer that has spread to other parts of the body in women who have experienced menopause. Drug firm Zydus Cadila on Friday …
Study finds breast cancer’s response to tumor stiffness may predict bone metastasis
Source: University of Arizona Health Sciences From: eurekalert.org In cases of breast cancer, bone metastasis – when cancer cells spread to new sites in the bone – causes the most breast cancer-related harm and is often incurable in advanced disease. A new study by University of Arizona Health Sciences researchers found that cancer cells become more aggressive when exposed to …
What Treatment Options Exist for Advanced Breast Cancer?
From: healthline.com Having an advanced form of cancer can feel like you have little or no treatment options. But that’s not the case. Find out what options are available to you and start getting on the right type of treatment. Hormone therapy There are several hormone therapies to treat advanced hormone receptor-positive (estrogen receptor-positive or progesterone receptor-positive) breast cancers: Tamoxifen …
Updated Guidelines Focus on Advanced Prostate Cancer
By: Tony Berberabe From: targetedonc.com “Men with advanced prostate cancer have exhausted local therapies and are now moving on to systemic options.” New guidelines issued jointly by the American Urological Association (AUA), American Society for Radiation Oncology (ASTRO), and Society of Urologic Oncology (SUO) focus on men withadvanced stage disease and now include new treatments, including the use of PARP …