From: precisiononcologynews.com The University of Southern California’s Norris Comprehensive Cancer Center on Monday said it has opened a Phase II trial of Ambrx’s antibody-drug conjugate ARX788 for advanced HER2-positive breast cancer patients. The trial, which is sponsored by La Jolla, California-based Ambrx, will involve roughly 200 HER2-positive metastatic breast cancer patients who have previously received trastuzumab emtansine (Genentech’s Kadcyla; T-DM1), …
Chemotherapy-Free Drug Combination Shows PFS Benefit for Women With HER2-Positive Breast Cancer
By: Caroline Hopkins From: precisiononcologynews.com Results from the Phase II monarcHER study published last week in Lancet Oncology demonstrated that women with advanced HER2-positive breast cancer may benefit from a combination of three non-chemotherapy agents: the CDK4/CDK6 inhibitor abemaciclib (Lilly’s Verzenio), the HER2-targeted therapy trastuzumab (Genentech’s Herceptin), and the anti-estrogen therapy fulvestrant (AstraZeneca’s Faslodex). The study showed a significant improvement …