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Novartis Kisqali significantly prolongs life in women with HR+/HER2- advanced breast cancer now in two distinct Phase III trials

In Clinical Trials by Barbara Jacoby

In MONALEESA-3, Kisqali plus fulvestrant achieved statistically significant improvement in overall survival in post-menopausal women in first- and second-line setting Kisqali is the only CDK4/6 inhibitor proven to prolong life with multiple combination partners These results build on the unique MONALEESA-7 data presented at ASCO 2019 showing overall survival benefit of Kisqali plus aromatase inhibitor in pre-/peri-menopausal women Full results …

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FDA Approves Qiagen’s PIK3CA Test as Companion Test for Novartis Breast Cancer Drug

In In The News by Barbara Jacoby

By: Staff Reporter From: genomeweb.com The US Food and Drug Administration has approved Qiagen’s Therascreen PIK3CA RGQ PCR Kit as a companion diagnostic for identifying which advanced breast cancer patients have PIK3CA mutations and are likely to respond to Novartis’ alpelisib (Piqray). The test is designed to analyze PIK3CA mutations in tissue and blood samples. Patients who are mutation negative …

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Positive CHMP Opinion for TALZENNA® (talazoparib) for Patients with Inherited (Germline) BRCA-Mutated Locally Advanced or Metastatic Breast Cancer

In Clinical Trials by Barbara Jacoby

Source: Business Wire From: yahoo.com Positive opinion based on results from largest Phase 3 trial performed to date of a PARP inhibitor in gBRCA-mutated advanced breast cancer Pfizer Inc. (PFE) today announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion recommending TALZENNA® (talazoparib), an oral poly (ADP-ribose) polymerase …

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Continuous chemotherapy improves outcomes and quality of life in advanced breast cancer

In Clinical Trials by Barbara Jacoby

Source: European Society for Medical Oncology From: eurekalert.org Continuous chemotherapy shows greater benefit in patients with advanced breast cancer by both improving survival and maintaining quality of life compared to intermittent scheduling, according to analyses of the Stop&Go study presented at the ESMO Breast Cancer Congress 2019, 2-4 May, Berlin, Germany. (1,2,3) The phase III study randomised 420 patients with …

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Alisertib-Based Combo Improves Survival Outcomes in Ovarian, Breast Cancer

In Clinical Trials by Barbara Jacoby

By: Jessica Skarzynski From: curetoday.com For some time now, paclitaxel has been considered standard of care in the treatment of patients with platinum-resistant ovarian cancer; however, recent research has shown the addition of the investigational drug alisertib to a paclitaxel regimen demonstrated promising activity in patients with recurrent ovarian cancer or advanced breast cancer. In the JAMA Oncology study, the …

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Study reveals new treatment option for women with advanced breast cancer resistant to hormone therapy

In In The News by Barbara Jacoby

Source: esmo.org From: news-medical.net Treatment with the cyclin dependent kinase (CDK) 4/6 inhibitor palbociclib achieves a clinically meaningful improvement in overall survival in patients with hormone receptor positive (HR+) human epidermal growth factor receptor-2 negative (HER2-) advanced breast cancer that has relapsed or progressed on hormonal therapy, according to the final analysis of overall survival results from the PALOMA-3 study …

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Advanced breast cancer patients can benefit from immunotherapy-chemotherapy combination

In Clinical Trials by Barbara Jacoby

Source: upmc.com From: news-medical.net Patients with an aggressive form of advanced breast cancer can benefit from immunotherapy when used in combination with chemotherapy as first-line treatment, according to the results of a large international Phase III clinical trial published today in the New England Journal of Medicine and led by a researcher at the UPMC Hillman Cancer Center and the …

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How Do I Know If My Advanced Breast Cancer Therapy Is Working?

In In The News by Barbara Jacoby

From: healthline.com Knowing if your current therapy treatment is truly doing everything it can to beat your breast cancer is, well, difficult to say the least. Here are some things to think about or consider. What are the symptoms of metastatic cancer? It’s not always easy to tell if cancer is progressing, despite treatment. That’s because it doesn’t always cause …