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Researchers advocate new approach to breast cancer prevention

In Clinical Studies News by Barbara Jacoby

By: Mayo Clinic From: medicalxpress.com A commentary by Mayo Clinic Cancer Center researchers published in the Journal of Clinical Oncology Practice suggests that advances in breast cancer prevention research have resulted in new and innovative opportunities to modify breast cancer risk and potentially reduce breast cancer incidence and mortality. “It is prudent for health care providers to be knowledgeable about …

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OneOncology Unveils Data Demonstrating Increased Utilization of Genomic and Biomarker Testing at Community Cancer Centers

In Clinical Studies News by Barbara Jacoby

Source: PRNewswire From: google.com OneOncology, the national platform for independent community oncology practices, and Genentech, a member of the Roche Group, presented data in two abstracts at the 2021 ASCO Quality Care Symposium examining genomic profiling and biomarker testing patterns in community oncology centers, as part of their multi-year strategic research partnership. Bringing personalized cancer treatment to patients in community cancer …

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Artificial Intelligence Tool Improves Accuracy of Breast Cancer Imaging

In Clinical Studies News by Barbara Jacoby

From: nyulangone.org A computer program trained to see patterns among thousands of breast ultrasound images can aid physicians in accurately diagnosing breast cancer, a new study shows. When tested separately on 44,755 already completed ultrasound exams, the artificial intelligence (AI) tool improved radiologists’ ability to correctly identify the disease by 37 percent and reduced the number of tissue samples, or …

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TransCode Therapeutics Announces Publication in Cancer Nanotechnology of Preclinical Data Supporting Therapeutic Potential of TTX-MC138 in Metastatic Breast Cancer

In Clinical Studies News by Barbara Jacoby

From: businesswire.com – Imaging study confirms the biodistribution of TTX-MC138 in models of metastatic cancer, supporting TransCode’s TTX platform for delivery of RNA targeted therapy to metastatic solid tumors – — eIND submission for TTX-MC138 anticipated in 1Q 2022 to support Phase 0 study in metastatic solid tumors, designed to establish proof of concept for TTX delivery platform — TransCode …

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Could Your Patient Benefit? New Clinical Trials in Breast Cancer

In Clinical Studies News by Barbara Jacoby

By: Helen Leask From: medscape.com A number of phase 3 studies in breast cancer have opened in recent months. Maybe one of your patients could benefit from being enrolled? Advanced HER2+ breast cancer. Patients with previously treated advanced or metastatic HER2+ breast cancer with and without brain metastases are sought for the DESTINY-B12 trial of trastuzumab deruxtecan (Enhertu). Patients will …

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Breast cancer researchers learn how to teach an old drug new tricks to help patients

In Clinical Studies News by Barbara Jacoby

By: Chris Malina From: wisc.edu Paclitaxel, or Taxol, is an old standby drug in the oncologist’s tool belt. Yet only about half of breast cancer patients treated with the drug see their tumors shrink or disappear, and doctors and researchers have no way of knowing which patients will benefit. But that may soon change. Published Sept. 8 in Science Translational …

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Breast cancers: Ruptures in cell nuclei promotes tumor invasion

In Clinical Studies News by Barbara Jacoby

Source: CNRS From: sciencedaily.com When cells multiply and migrate, they can be compressed and their nucleus may break open. This phenomenon causes DNA damage. Scientists have now shown that this facilitates the spread of cancer cells in breast tumors. The nucleus of a cell fills a crucial function: to protect cell DNA and enable its proper use. But it can …

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Accutar Biotechnology Announces FDA Clearance of IND Application for Phase 1 Trial of AC0682 in ER-Positive Breast Cancer

In Clinical Studies News by Barbara Jacoby

From: businesswire.com Accutar Biotechnology, Inc., a biotechnology company focusing on artificial intelligence (AI)-enabled drug discovery, today announced that the U.S. Food and Drug Administration (FDA) has cleared the company’s investigational new drug application (IND) for AC0682 for the treatment of patients with estrogen receptor (ER)-positive breast cancers. AC0682 is an orally bioavailable, chimeric degrader molecule designed to target and degrade …

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IL13Ra2 revealed as target against breast cancer-related brain metastasis

In Clinical Studies News by Barbara Jacoby

From: drugtargetreview.com A new study conducted by the University of Colorado, US, has looked specifically at the role of interleukin 13 receptor alpha 2 (IL13Ra2), a protein that is found in increased rates in cancer cells that metastasise to other locations in the body – particularly the brain and lungs. The team used experimental HER2 breast-brain metastases models both in …

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AstraZeneca announces ‘groundbreaking’ results in new breast cancer drug trial

In Clinical Studies News by Barbara Jacoby

By: TOI Staff From: timesofisrael.com 72% of trial patients administered Enherthu showed no progression in their cancer after 12 months, compared to 34.1% of those treated with the current standard of care medication British pharmaceutical giant AstraZeneca announced Sunday “groundbreaking” results in a trial of a new breast cancer drug which they say has been proven to reduce the risk …