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FDA grants fast track designation to ARX788 for breast cancer subset

In In The News by Barbara Jacoby

Source: HemOnctoday From: healio.com The FDA granted fast track designation to ARX788 as monotherapy for certain patients with HER2-positive breast cancer. The designation applies to use of the agent for patients with advanced or metastatic disease who received at least one prior anti-HER2-based regimen in the metastatic setting. ARX788 (Ambrx) — an antibody-drug conjugate that targets the HER2 receptor — …

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Most breast cancer patients satisfied ‘going flat’ after mastectomy

In In The News by Barbara Jacoby

By: Chris Melore From: studyfinds.org A mastectomy can be a life-changing decision for women dealing with or at high-risk for breast cancer. While many women opt for breast reconstruction, a new study finds more women are “going flat” after surgery. Researchers from UCLA say although most of these women are happy with their choice, nearly a quarter feel unsupported by …

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Researchers reveal distinct molecular signature in tumor tissues of Black breast cancer patients

In In The News by Barbara Jacoby

Source: Roswell Park Comprehensive Cancer Center From: news-medical.net A Roswell Park Comprehensive Cancer Center team led by Christine Ambrosone, PhD, and Song Yao, PhD, has revealed a distinct molecular signature in the tumor tissues of Black patients with breast cancer. The new work, published today in JNCI, the Journal of the National Cancer Institute, reports that an elevated number of …

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Your Cancer Answers: Which genetic syndromes increase the risk of breast cancer?

In In The News by Barbara Jacoby

By: Dr. Kevin Lin  From: lompocrecord.com Question: Which genetic syndromes increase the risk of breast cancer? Many risk factors for breast cancer have been identified, including genetic, environmental, and lifestyle factors. Some are modifiable and others are not. A family history of breast cancer in a first-degree relative is the most widely recognized breast cancer risk factor, but only 5-10% …

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Women of All Ages with Breast Cancer Experience the Same Levels of Symptom Severity

In In The News by Barbara Jacoby

By: Colleen Moretti From: curetoday.com Both older and younger women with early breast cancer (EBC) being treated with the same chemotherapy experienced around the same levels of symptom severity and symptom-related adverse events, according to a study published in Cancer. It was unknown whether there was patient-reported symptom severity and symptom interference with daily activities difference in women under the …

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Breast cancer abutting the pectoralis major muscle on breast MRI: what are the clinical implications?

In In The News by Barbara Jacoby

Source: PubMed From: docwirenews.com Objectives: Defining the posterior extent of breast cancer prior to surgery has clinical implications. However, there is limited data available to guide the interpretation of breast cancers seen on MRI that abut the pectoralis muscle but lack associated muscle enhancement. Methods: In this retrospective study of breast MRIs performed between May 2008 and July 2019, 43 female patients …

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HRQoL effects of breast cancer prognosis, treatment predict mortality risk

In In The News by Barbara Jacoby

By: Hannah Kitt From: medwirenews.com The health-related quality of life (HRQoL) of patients with ductal carcinoma in situ (DCIS) or invasive breast cancer is impaired by their prognosis and treatment, and measuring the extent of impairment could help predict mortality risk, research suggests. Dale Sandler (National Institutes of Health, Research Triangle Park, North Carolina, USA) and co-investigators say: “The evaluation …

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Older Women Without Breast Cancer May Inappropriately View Certain Treatment Options as Negatively Impacting Prognosis

In In The News by Barbara Jacoby

By: Colleen Moretti From: curetoday.com Older women without hormone receptor (HR) positive breast cancer are still experiencing overtreatment despite national recommendations to omit, due to lack of reframing prognosis and education on treatment risks, according to a study published in Jama. “Positive reframing of recommendations to avoid (sentinel lymph node biopsy) and radiotherapy may be a strategy to reduce overtreatment …

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Drug-loaded nanoparticles dissolve only in cancer cells

In In The News by Barbara Jacoby

By: Michael Irving From: newatlas.com Killing cancer cells isn’t particularly hard – the tricky part is doing so without harming healthy cells. Researchers at Ludwig Maximilian University of Munich (LMU) have developed nanoparticles that selectively release drugs inside tumors, while keeping them safely locked away when in healthy cells. Currently, radiation and chemotherapy are the leading treatments for cancer, but …

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Regulatory RNAs promote breast cancer metastasis

In In The News by Barbara Jacoby

Source: Cold Spring Harbor Laboratory From: prnewswire.com Cold Spring Harbor Laboratory (CSHL) scientists have discovered a gene-regulating snippet of RNA that may contribute to the spread of many breast cancers. In animal experiments, the researchers could reduce the growth of metastatic tumors with a molecule designed to target that RNA and trigger its destruction. The same strategy, they say, could …