View Post

Alternative cancer cell fuel source targeted as therapeutic approach for breast cancer

In In The News by Barbara Jacoby

Source: The Wistar Institute From: eurekalert.org New small molecule inhibitor impairs cancer growth in preclinical models by depriving malignant cells of a critical nutrient source Scientists at The Wistar Institute characterized an inhibitor that targets acetate metabolism in cancer cells. Cancer cells use acetate metabolism to support tumor growth in conditions of low nutrient and oxygen availability. This molecule caused …

View Post

Statins during chemo may limit heart damage in breast cancer patients

In In The News by Barbara Jacoby

By: Erica Carbajal From: beckershospitalreview.com Women with early breast cancer who received statins, or cholesterol-lowering drugs, during their chemotherapy had a lower risk of heart failure in the five years after their cancer treatment, according to a study published in the Journal of the American Heart Association Jan. 6. Researchers analyzed data from newly diagnosed breast cancer patients age 66 …

View Post

FDA grants fast track designation to ARX788 for breast cancer subset

In In The News by Barbara Jacoby

Source: HemOnctoday From: healio.com The FDA granted fast track designation to ARX788 as monotherapy for certain patients with HER2-positive breast cancer. The designation applies to use of the agent for patients with advanced or metastatic disease who received at least one prior anti-HER2-based regimen in the metastatic setting. ARX788 (Ambrx) — an antibody-drug conjugate that targets the HER2 receptor — …

View Post

Most breast cancer patients satisfied ‘going flat’ after mastectomy

In In The News by Barbara Jacoby

By: Chris Melore From: studyfinds.org A mastectomy can be a life-changing decision for women dealing with or at high-risk for breast cancer. While many women opt for breast reconstruction, a new study finds more women are “going flat” after surgery. Researchers from UCLA say although most of these women are happy with their choice, nearly a quarter feel unsupported by …

View Post

Researchers reveal distinct molecular signature in tumor tissues of Black breast cancer patients

In In The News by Barbara Jacoby

Source: Roswell Park Comprehensive Cancer Center From: news-medical.net A Roswell Park Comprehensive Cancer Center team led by Christine Ambrosone, PhD, and Song Yao, PhD, has revealed a distinct molecular signature in the tumor tissues of Black patients with breast cancer. The new work, published today in JNCI, the Journal of the National Cancer Institute, reports that an elevated number of …

View Post

Your Cancer Answers: Which genetic syndromes increase the risk of breast cancer?

In In The News by Barbara Jacoby

By: Dr. Kevin Lin  From: lompocrecord.com Question: Which genetic syndromes increase the risk of breast cancer? Many risk factors for breast cancer have been identified, including genetic, environmental, and lifestyle factors. Some are modifiable and others are not. A family history of breast cancer in a first-degree relative is the most widely recognized breast cancer risk factor, but only 5-10% …

View Post

Women of All Ages with Breast Cancer Experience the Same Levels of Symptom Severity

In In The News by Barbara Jacoby

By: Colleen Moretti From: curetoday.com Both older and younger women with early breast cancer (EBC) being treated with the same chemotherapy experienced around the same levels of symptom severity and symptom-related adverse events, according to a study published in Cancer. It was unknown whether there was patient-reported symptom severity and symptom interference with daily activities difference in women under the …

View Post

Breast cancer abutting the pectoralis major muscle on breast MRI: what are the clinical implications?

In In The News by Barbara Jacoby

Source: PubMed From: docwirenews.com Objectives: Defining the posterior extent of breast cancer prior to surgery has clinical implications. However, there is limited data available to guide the interpretation of breast cancers seen on MRI that abut the pectoralis muscle but lack associated muscle enhancement. Methods: In this retrospective study of breast MRIs performed between May 2008 and July 2019, 43 female patients …

View Post

HRQoL effects of breast cancer prognosis, treatment predict mortality risk

In In The News by Barbara Jacoby

By: Hannah Kitt From: medwirenews.com The health-related quality of life (HRQoL) of patients with ductal carcinoma in situ (DCIS) or invasive breast cancer is impaired by their prognosis and treatment, and measuring the extent of impairment could help predict mortality risk, research suggests. Dale Sandler (National Institutes of Health, Research Triangle Park, North Carolina, USA) and co-investigators say: “The evaluation …

View Post

Older Women Without Breast Cancer May Inappropriately View Certain Treatment Options as Negatively Impacting Prognosis

In In The News by Barbara Jacoby

By: Colleen Moretti From: curetoday.com Older women without hormone receptor (HR) positive breast cancer are still experiencing overtreatment despite national recommendations to omit, due to lack of reframing prognosis and education on treatment risks, according to a study published in Jama. “Positive reframing of recommendations to avoid (sentinel lymph node biopsy) and radiotherapy may be a strategy to reduce overtreatment …