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Targeting triple-negative breast cancer with new drug design

In In The News by Barbara Jacoby

By: Laura Castañón, Northeastern University From: medicalxpress.com The type of breast cancer most likely to affect young people and African Americans is also one of the most aggressive and difficult to treat. Triple-negative breast cancer, which represents about 20 percent of all breast cancer cases, is named for its lack of three common hormone receptors. Since targeted breast cancer treatments …

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New role for a driver of metastatic cancers

In In The News by Barbara Jacoby

Source: Salk Institute for Biological Studies From: prnewswire.com Salk scientists uncover the mechanism of a gene to better target cancer therapy Metastatic ovarian, prostate and breast cancers are notoriously difficult to treat and often deadly. Now, Salk Institute researchers have revealed a new role for the CDK12 protein. The findings were published in the print version of Genes & Development …

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Breast cancer study by UCR medical student could help patients live longer

In In The News by Barbara Jacoby

By: Iqbal Pittalwala From: ucr.edu A student at the University of California, Riverside, presented research results at the annual meeting of the American Association for Cancer Research, or AACR, in Atlanta showing that surgery is associated with higher survival rates for patients with HER2-positive stage 4 breast cancer compared with those who did not undergo surgery. The protein HER2, or …

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Major step towards individual cancer immunotherapy

In In The News by Barbara Jacoby

By: Fabio Bergamin From: medicalxpress.com T cells become active in the body only when they recognise a peptide located on one of the immune system’s sentinel cells. The ETH scientists repurposed sentinel cells in such a way that they indicate which peptides the T cells recognise. Medicine has great hopes for personalised cancer immunotherapy. The idea is to have a …

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Are You Dense?

In In The News by Barbara Jacoby

By: Bonnie Annis From: curetoday.com Are you dense? I’m not referring to your mental abilities, I’m referring to your breasts. Have you felt them lately? I’m very concerned with your answer and so is the Food and Drug Administration (FDA), it seems. For the first time in over 20 years, the FDA feels amendments to current regulations would not only improve …

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Public domain antibiotic found highly effective against triple-negative breast cancer

In In The News by Barbara Jacoby

Source: University of Geneva From: medicalxpress.com Of the three major subtypes of breast cancer, triple negative is the most lethal. Half of all breast cancer deaths are attributed to it, whereas it accounts for only about 15 percent of incidences of breast cancer. And unlike other breast cancers, it is resistant to most existing therapies. By studying the properties of …

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PBM Delays for Cancer Drugs May Risk Lives, Warn Oncologists

In In The News by Barbara Jacoby

By: Alicia Ault From: medscape.com The patient had metastatic kidney cancer, and his oncologist was seeking to treat him with sunitinib malate (Sutent, Pfizer), a preferred first-line oral therapy. But the patient’s pharmacy benefit manager (PBM) refused to cover the cost of the medication. The PBM told the oncologist that the patient’s kidney must first be removed. However, the patient’s …

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Estrogen May Trigger Brain Metastasis in Triple-negative Breast Cancer, Study Shows

In In The News by Barbara Jacoby

By: Ana Pena From: breastcancer-news.com Estradiol, a type of estrogen and the major female hormone, may drive the spread of cancer to the brain in women with triple-negative breast cancer (TNBC), a study in mice and human cells reports. Researchers identified a chain of molecular events triggered by estradiol that appears to be behind tumor cells’ ability to form brain …

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Psychosocial, Behavioral and Communication Issues Remain in Breast Cancer Trajectory

In In The News by Barbara Jacoby

By: Kristie L. Kahl From: curetoday.com Enormous progress has been made in breast cancer, yet many challenges remain, according to Ann H. Partridge, M.D., MPH. Enormous progress has been made in breast cancer, yet many challenges remain, according to Ann H. Partridge, M.D., MPH. For example, diagnosis and treatment for the disease have come a long way, yet, in the …