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Gene variants foretell the biology of future breast cancers in Stanford Medicine study

In In The News by Barbara Jacoby

By: Krista Conger From: stanford.edu A Stanford Medicine study of thousands of breast cancers has found that the gene sequences we inherit at conception are powerful predictors of the breast cancer type we might develop decades later and how deadly it might be. The study challenges the dogma that most cancers arise as the result of random mutations that accumulate …

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Study Reveals Worse Clinical Outcomes in Breast Cancer Patients Who Reported Higher Pain and Stress

In In The News by Barbara Jacoby

By: Roswell Park Comprehensive Cancer Center From: newswise.com More studies needed to determine if reducing pain & stress could improve survival Investigators looked for links between inflammation-related factors & outcomes Phase 3 clinical trial enrolled more than 3,000 patients Secondary analyses of a phase 3 clinical trial have revealed that breast cancer patients who reported high levels of pain and stress …

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New study advocates for de-escalating breast cancer surgery in women aged 55 and older

In In The News by Barbara Jacoby

Source: University of Pittsburgh From: news-medical.net Surgery involving sentinel lymph node biopsy for middle-aged women with estrogen receptor-positive (ER+) breast cancer may do more harm than good, according to a new study led by University of Pittsburgh and UPMC Hillman Cancer Center researchers. The team used a novel artificial intelligence pipeline developed by Realyze Intelligence, a UPMC Enterprises portfolio company, to analyze electronic …

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Scientists Find Potential “Achilles’ Heel” of Drug-Resistant Breast Cancer

In In The News by Barbara Jacoby

From: insideprecisionmedicine.com Researchers at the Baylor College of Medicine have identified a protein called PKMYT1 as a promising marker for a form of drug-resistant breast cancer, as well as a potential drug target for patients that currently face a very poor prognosis. Up to 80 percent of deaths from breast cancer are caused by estrogen receptor-alpha-positive (ER+) tumors. The standard …

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Innovative Staging System for De Novo Metastatic Breast Cancer Validated Internationally

In In The News by Barbara Jacoby

By: Chase Doyle From: ascopost.com A ground breaking staging system for de novo metastatic breast cancer has been validated in an international cohort, perhaps paving the way for more personalized care and improved outcomes for patients diagnosed with this challenging disease. The staging system, developed by surgical oncologist Jennifer K. Plichta, MD, MS, of Duke University School of Medicine, stratifies patients …

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Study examines metabolic reprogramming of breast cancer tumors during neoadjuvant chemotherapy

In In The News by Barbara Jacoby

By: Karolinska Institutet From:medicalxpress.com In a study published in Nature Communications, scientists have made significant strides in understanding the complex interplay between the immune system and cancer metabolism in breast cancer treatment. The research offers new insights into how the immune state and cancer metabolism evolve during neoadjuvant chemotherapy (NAC). The study utilized proteomics, genomics, transcriptomics and histopathology to analyze tumor tissue …

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The Alcohol and Breast Cancer Connection

In In The News by Barbara Jacoby

From: bcrf.org Did you know alcohol is a carcinogen? If not, you’re far from alone. For years, the national dialog around alcohol use has centered around wine’s purported heart health benefits, thanks to muddied public health and media messaging and industry lobbying. A study in the journal Cancer Epidemiology, Biomarkers & Prevention found that more than half of adults don’t …

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Ribociclib Plus Endocrine Therapy Demonstrates PFS Advantage in HR+/HER2– Advanced Breast Cancer

In In The News by Barbara Jacoby

By: Kyle Doherty From: onclive.com Frontline treatment with ribociclib (Kisqali) in combination with endocrine therapy displayed a significant progression-free survival (PFS) benefit with superior tolerability vs combination chemotherapy in patients with clinically aggressive hormone receptor–positive, HER2-negative advanced breast cancer, according to findings from the phase 2 RIGHT Choice trial (NCT03839823) published in the Journal of Clinical Oncology. At a median …

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New way to kill cancer cells could lead to longer lasting protection for people with breast cancer

In In The News by Barbara Jacoby

From: icr.ac.uk Killing breast cancer cells in a way that trains the immune system to recognise and destroy residual cancer cells could offer longer lasting protection to people with the disease. The early-stage discovery published in the journal Immunity, shows that by causing cancer cells to undergo a process called immunogenic cell death, the immune system is switched on and …

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ASTRO guideline on radiation therapy for bone mets emphasizes patient-centered care

In In The News by Barbara Jacoby

he American Society for Radiation Oncology (ASTRO) published yesterday an updated clinical guideline that details best practices for treating patients who have symptomatic bone metastases and ways to improve their quality of life. The guideline is available as a free access article in Practical Radiation Oncology, ASTRO’s clinical practice journal. Many types of cancer can spread to a patient’s skeletal …