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Relationship of Radiation Dose to Efficacy of Radioembolization of Liver Metastasis from Breast Cancer

In Clinical Trials by Barbara Jacoby

From: mdlinx.com Highlights Higher radiation dose to breast cancer liver metastases during radioembolization is associated with objective response. A dose threshold to tumor of 79.5 Gy is proposed to achieve objective response. Longer survival is associated with objective response. Shorter survival is associated with worse pre-radioembolization liver function, bilobar disease, and radioembolization-associated liver impairment. Accurate pre-treatment dosimetry may help optimize response …

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Inpatient mammograms can reduce disparities in breast cancer screening rates

In In The News by Barbara Jacoby

Source: Massachusetts General Hospital From: eurekalert.org Completing cancer screening tests, such as mammograms, can be challenging for low-income people, who may face such challenges as lack of transportation or inability to take time off work. A team at Massachusetts General Hospital (MGH) explored the possibility of addressing preventive care needs when patients are admitted to the hospital. The pilot study, …

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Strata Oncology Announces Personalized Recurrence Monitoring Trial

In Clinical Trials by Barbara Jacoby

From: PR Newswire Study to Evaluate Strata’s Ability to Detect Tumor Recurrence using Liquid Biopsy and Monitor Treatment Effectiveness for Patients with Early-Stage Solid Tumors Strata Oncology, Inc., a precision oncology company advancing molecular indications for cancer therapies, today announced plans to begin enrolling the Sentinel Trial in the first half of 2021. Sentinel is a prospective, observational study designed …

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New Research in JNCCN Highlights Dangerous Disparities for Life-Saving Cancer Screening

In In The News by Barbara Jacoby

Study finds more work is needed to enhance adherence to recommended cancer screening in Canada. New research in the January 2021 issue of JNCCN—Journal of the National Comprehensive Cancer Network finds more than a third of eligible people miss timely screening tests for colorectal cancer and at least a quarter appear to miss timely screening tests for breast and cervical …

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DarwinHealth Scientists Publish Foundational Research Identifying Regulatory Mechanisms Controlling Cancer Cell States and Drug Response

In Clinical Trials by Barbara Jacoby

From: PR Newswire DarwinHealth, Inc., a New York-based biotechnology and cancer drug discovery company announces the January 11, 2021 online publication in Cell of a landmark paper, “A Modular Master Regulator Landscape Controls Cancer Transcriptional Identity,”1,2 in which scientists from Columbia University and DarwinHealth apply the VIPER (Virtual Inference of Protein activity by Enriched Regulon) analysis algorithm to identify recurrent regulatory networks—”tumor …

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UTSW researchers identify new gene involved in breast cancer growth

In In The News by Barbara Jacoby

Source: UT Southwestern Medical Center From: eurekalert.org A team of UT Southwestern researchers has identified a gene involved in the growth of breast cancer, a finding that could lead to potential new targets for treatment. “The gene ZMYND8 is increased in breast cancer conditions, and higher levels of the gene correlate with poor survival of breast cancer patients,” says Yingfei …

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Uptake of Breast Cancer Clinical Trials at Minority Serving Cancer Centers

In Clinical Trials by Barbara Jacoby

By: DocWire News Featured Reading From: docwirenews.com ABSTRACT BACKGROUND: Most minorities receive cancer care at minority-serving hospitals (MSHs) that have been associated with disparate treatment between Black and White patients. OBJECTIVE: Our aim was to examine the uptake of clinical trials that have changed axillary management in breast cancer patients at MSH and non-MSH cancer centers. METHODS: The National Cancer …

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Financial Toxicity Linked to QOL After Breast Cancer Surgery

In In The News by Barbara Jacoby

Source: Physician’s Briefing Staff From: healthday.com Strongest correlation seen for BREAST-Q psychosocial well-being, with 0.89 change per unit change in financial toxicity score Financial toxicity (FT) is associated with worse quality of life (QOL) for breast cancer patients after mastectomy or lumpectomy, according to a study published online Dec. 11 in the Journal of the American College of Surgeons. Christopher …

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Triple-Negative Breast Cancer: Assessing the Role of Immunohistochemical Biomarkers on Neoadjuvant Treatment

In Clinical Trials by Barbara Jacoby

From: dovepress.com Objective: This study aimed to investigate the influence of immunohistochemical (IHC) biomarkers in the response to neoadjuvant chemotherapy (NACT) and survival outcomes in the subset of locally advanced triple-negative breast cancer (TNBC). Materials and Methods: The epidermal growth factor receptor (EGFR), androgen receptor (AR), cytokeratins (CK5/6, CK14 and CK17), Ki67 and p53 immunohistochemistry were evaluated on 171 cases …