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Servier, in Collaboration with Allogene Therapeutics, Announces FDA Clearance of the IND for ALLO-501, an anti-CD19 Allogeneic CAR T (AlloCAR T) Therapy

In Clinical Trials by Barbara Jacoby

Source: Allogene Therapeutics Allogene to Initiate the ALPHA Study for ALLO-501 in Relapsed/Refractory Non-Hodgkin Lymphoma ALLO-647, Allogene’s Proprietary anti-CD52 Antibody, Will be Administered as Part of the Lymphodepletion Regimen Paris (France) and South San Francisco, Calif. – January 28, 2019 – Servier, an independent international pharmaceutical company and Allogene Therapeutics, Inc. (Nasdaq: ALLO), a clinical- stage biotechnology company pioneering the …

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Fibrosis-targeting drugs may benefit patients with late-stage, metastatic breast cancer

In In The News by Barbara Jacoby

Source: massgeneral.org From: news-medical.net A Massachusetts General Hospital (MGH) research team has found that the overgrowth of connective called fibrosis may block the effectiveness of immunotherapies against metastatic breast cancer. Their report published in PNAS also finds that plerixafor, a drug approved to mobilize blood system stem cells in the treatment of lymphoma and multiple myeloma patients, can reduce fibrosis …

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New breast imagine modality may reduce unnecessary biopsies by up to 45 percent

In Clinical Trials by Barbara Jacoby

By: Lisa Chamoff From: dotmed.com Researchers at Washington University in St. Louis predict a new breast imaging modality that combines ultrasound and near-infrared imaging, or diffuse light tomography, can reduce unnecessary biopsies by up to 45 percent. The team — Quing Zhu, professor of biomedical engineering at the Washington University in St. Louis School of Engineering & Applied Science and …

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Innovative Ice-Free Scalp Cooling During Chemotherapy Prevents, Reduces Hair Loss for Breast Cancer Patients

In In The News by Barbara Jacoby

Source: Henry Ford Health System From: newswise.com Breast cancer patient Laura Carey returned to work one week after beginning chemotherapy, but without a demoralizing side-effect indicative of this type of cancer treatment – hair loss. Carey is among the first breast cancer patients at the Henry Ford Cancer Institute to successfully prevent and reduce hair loss during chemotherapy by using …

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OncoQuest Lays the Groundwork for Commencement of Phase 3 Study in Frontline Ovarian Cancer

In Clinical Trials by Barbara Jacoby

Source: OncoQuest, Inc. From: prnewswire.com OncoQuest Inc., a privately held, cancer immunotherapy company, has retained the services of IQVIA, a company formed through the merger of IMS Health and Quintiles, to manage OncoQuest’s planned Phase 3 clinical study in frontline ovarian cancer with the company’s lead product candidate, oregovomab, an anti-CA-125 antibody. OncoQuest will collaborate with IQVIA, a leading global …

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Cutting-edge MRI-guided radiation therapy provides real-time view of tumors

In In The News by Barbara Jacoby

By: Ronda Wendler From: mdanderson.org An innovative new technology is now providing radiation oncologists at MD Anderson Cancer Center a real-time view of tumors while they use cancer-killing radiation beams. These live images help keep the radiation beam directly on target throughout every treatment, allowing for a degree of precision and monitoring capabilities that were not previously possible. Marriage of …

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Inovio Reports 2nd Patient Achieving Full Remission from HPV-Related Head & Neck Cancer after Treatment with Synthetic DNA Vaccine and a PD-1 Checkpoint Inhibitor

In Clinical Trials by Barbara Jacoby

From: prnewswire.com Inovio Pharmaceuticals, Inc. (NASDAQ: INO) today announced that a second patient with HPV-related head and neck cancer treated with INO-3112 (now called MEDI0457) in a Phase 1 trial achieved a sustained complete response (full remission) after subsequent treatment with a PD-1 checkpoint inhibitor. This marks the second patient with metastatic cancer observed in full remission (complete response) after treatment …

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In surprising reversal, scientists find a cellular process that stops cancer before it starts

In In The News by Barbara Jacoby

Source: Salk Institute for Biological Studies From: prnewswire.com Salk research shows that cellular recycling process, thought to fuel cancer’s growth, can actually prevent it Just as plastic tips protect the ends of shoelaces and keep them from fraying when we tie them, molecular tips called telomeres protect the ends of chromosomes and keep them from fusing when cells continually divide …